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Green Synthesis of Plant-Based Nanoparticles: Influence of Physicochemical Factors on Formation and Stability

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 20 January 2027 | Viewed by 3885

Editors


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Guest Editor
Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: coordination chemistry; metal complexes with bioactive ligands; polyphenol–metal interactions; bioinorganic chemistry; antioxidant metal-based compounds; transition metal complexes; spectroscopic characterization of coordination compounds; biological evaluation of metal complexes; medicinal inorganic chemistry; metal-based therapeutic agents
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
Interests: neuroprotection; natural molecules; antioxidants; pharmacology; healthcare; biotechnologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The sustainable and eco-friendly synthesis of nanoparticles using plant extracts has emerged as a promising approach in nanotechnology, offering advantages such as biocompatibility, reduced toxicity, and cost-effectiveness compared with conventional chemical or physical methods. Plant-derived phytochemicals, including polyphenols, flavonoids, terpenoids, and alkaloids, play a crucial role in reducing metal ions and stabilizing nanoparticles. However, the characteristics and properties of the resulting nanomaterials are highly dependent on several experimental parameters.

This Special Issue aims to highlight recent advances in the green synthesis of nanoparticles using various plant extracts, with a particular focus on how factors such as pH, molar ratios of precursors, reaction time, and temperature influence particle formation, morphology, stability, and biological activity. Contributions addressing systematic optimization, mechanistic insights, and structure–function relationships are especially encouraged. Both original research articles and comprehensive reviews are welcome. By gathering the current knowledge in this area, the Special Issue intends to provide valuable perspectives on tailoring plant-based nanoparticles for biomedical, environmental, and technological applications, thus advancing the field of green nanotechnology.

Dr. Ionut-Iulian Lungu
Prof. Dr. Oana Cioanca
Guest Editors

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Keywords

  • green synthesis
  • plant extracts
  • metallic nanoparticles
  • physicochemical parameters
  • pH and temperature effects
  • reaction kinetics
  • ionic precursors
  • stability and aggregation
  • eco-friendly nanotechnology
  • bio-based nanomaterials

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Published Papers (2 papers)

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Research

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25 pages, 1235 KB  
Article
Antioxidant Activity and UV-Absorbing Properties of Artemisia annua L.: Phytochemical and In Silico Insights
by Mariana Panțuroiu, Mirela Antonela Mihăilă, Carmen Elisabeta Manea and Mona Luciana Gălățanu
Appl. Sci. 2026, 16(17), 8501; https://doi.org/10.3390/app16178501 - 26 Aug 2026
Abstract
Artemisia annua L. is a medicinal plant characterized by a chemically diverse phytochemical profile and potential relevance for cosmetic and dermatological applications. This study investigated a hydroethanolic A. annua extract through phytochemical characterization, antioxidant evaluation, UV–Vis-based assessment of UV absorption, and exploratory molecular [...] Read more.
Artemisia annua L. is a medicinal plant characterized by a chemically diverse phytochemical profile and potential relevance for cosmetic and dermatological applications. This study investigated a hydroethanolic A. annua extract through phytochemical characterization, antioxidant evaluation, UV–Vis-based assessment of UV absorption, and exploratory molecular docking. HPLC-DAD-MS/MS supported the assignment and quantitative determination of artemisinin, chlorogenic acid, and isoquercitrin at 0.09, 0.11, and 0.21 mg/mL extract, respectively. GC–MS revealed a diverse composition comprising primary and secondary metabolites, while separate essential oil characterization identified Artemisia ketone as the predominant volatile constituent. Total phenolic and flavonoid contents were 16.82 ± 0.29 mg GAE/g DW and 1.46 ± 0.14 mg RE/g DW, respectively. Concentration-dependent antioxidant activity was observed in DPPH and ABTS assays, with IC50 values of 0.77 ± 0.13 and 0.092 mg dry plant material equivalent/mL reaction mixture, respectively. UV–Vis analysis showed concentration-dependent increases in spectrophotometrically estimated SPF within the evaluated analytical range. At 1.25 mg/mL, the extract exhibited an SPF estimate of 7.20 ± 0.35, a UVA/UVB absorbance ratio of 2.58, and a critical wavelength of 379.3 nm, indicating that UV absorption extended substantially into the UVA region. Exploratory molecular docking yielded the most favorable AutoDock Vina scores for chlorogenic acid toward MMP-1 (−9.0 kcal/mol) and isoquercitrin toward human neutrophil elastase (−8.0 kcal/mol). Overall, A. annua represents a source of phytochemicals with experimentally demonstrated antioxidant activity and measurable UV-absorbing properties, supporting further investigation in appropriately formulated and validated topical systems. Full article

Review

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16 pages, 844 KB  
Review
Plant-Derived Nanomaterials and Protein Misfolding Disorders: Green Production Approaches, Biological Interactions, and Research Trends (2015–2025)
by Corina Dalia Toderescu, Iulia Cresneac, Alexandru Oancea, Svetlana Trifunschi, Melania Florina Munteanu and Casiana Boru
Appl. Sci. 2026, 16(5), 2620; https://doi.org/10.3390/app16052620 - 9 Mar 2026
Cited by 1 | Viewed by 718
Abstract
Protein misfolding and aggregation represent key pathological mechanisms in neurodegenerative and systemic amyloid disorders, yet disease-modifying therapeutic strategies remain limited. In recent years, plant-derived nanomaterials have attracted increasing attention as multifunctional platforms capable of interacting with misfolded proteins and modulating aggregation-related pathways. This [...] Read more.
Protein misfolding and aggregation represent key pathological mechanisms in neurodegenerative and systemic amyloid disorders, yet disease-modifying therapeutic strategies remain limited. In recent years, plant-derived nanomaterials have attracted increasing attention as multifunctional platforms capable of interacting with misfolded proteins and modulating aggregation-related pathways. This review examines the evolution of research between 2015 and 2025 on plant-derived nanomaterials—including green-synthesized metallic nanoparticles, plant extracellular vesicles, and phytochemical-based nano-delivery systems—in the context of protein misfolding disorders. The available literature was analyzed to identify principal mechanisms of action, experimental models, and emerging therapeutic perspectives. Current evidence suggests that these nanomaterials may influence protein aggregation through direct molecular interactions, modulation of oxidative stress and neuroinflammatory responses, and enhancement of cellular protein clearance processes. However, the field remains characterized by methodological heterogeneity, limited standardization, and insufficient translational validation. By synthesizing recent developments, this review highlights key research trends, mechanistic gaps, and future directions necessary for advancing plant-derived nanomaterials toward biomedical applications targeting protein misfolding diseases. Full article
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