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Periodontal Therapy: Latest Advances and Prospects

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1872

Special Issue Editors


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Guest Editor
Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Interests: oral microbiome; periodontal disease; periodontal treatment

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Guest Editor
Department of Diagnosis and Surgery, Periodontics Division, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015050, SP, Brazil
Interests: odontology; periodontology; laser; dental implants

Special Issue Information

Dear Colleagues,

In recent years, periodontology has undergone significant transformation driven by advances in biomedical science, digital innovation, and a deeper understanding of the oral–systemic connection. The integration of smart technologies, biomaterials, host-modulation therapies, and microbiome-targeted strategies is shaping a new era of precision periodontal care.

From diagnosis to treatment, novel approaches in periodontology are rapidly emerging. This Special Issue invites submissions that explore the latest advancements and future directions in periodontal therapy. We welcome original research articles, literature reviews, and case studies addressing the following topics:

  • Digital tools and diagnostics in periodontology;
  • Oral microbiome;
  • Host-modulatory and anti-inflammatory therapies;
  • Periodontal and peri-implant disease;
  • Periodontal and peri-implant therapy;
  • Periodontal regeneration and biomaterials;
  • Translational and personalized periodontal medicine.

We encourage contributions that highlight interdisciplinary collaboration and emphasize the clinical impact of emerging technologies and research. By sharing knowledge and innovations, we can collectively advance the science and practice of periodontology.

We look forward to your valuable contributions to this Special Issue.

Dr. Natalia De Campos Kajimoto
Prof. Dr. Juliano Milanezi De Almeida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal and peri-implant disease
  • periodontal therapy
  • oral microbiome
  • host modulation
  • regenerative periodontics
  • antimicrobial strategies
  • oral–systemic health
  • biomaterials
  • translational dental research
  • smart technology in periodontal care

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Published Papers (2 papers)

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Review

17 pages, 652 KB  
Review
The Adjunctive Role of Probiotics in Periodontal Therapy: A Narrative Review
by Natalia de Campos Kajimoto, Cristhiam de Jesus Hernandez Matinez, Peter Michael Loomer, Yvonne de Paiva Buischi and Ana Carolina Punhagui Hernandes
Appl. Sci. 2026, 16(8), 3753; https://doi.org/10.3390/app16083753 - 11 Apr 2026
Viewed by 363
Abstract
Periodontitis is a chronic inflammatory disease driven by microbial dysbiosis and an exacerbated host immune response. This leads to progressive breakdown of periodontal tissues. Although scaling and root planing remains the standard treatment, its capacity to fully restore immune balance and host–microbiota homeostasis [...] Read more.
Periodontitis is a chronic inflammatory disease driven by microbial dysbiosis and an exacerbated host immune response. This leads to progressive breakdown of periodontal tissues. Although scaling and root planing remains the standard treatment, its capacity to fully restore immune balance and host–microbiota homeostasis is limited. Probiotics have emerged as promising adjunctive strategies to modulate pathways involved in periodontal disease progression. This review aimed to evaluate current clinical evidence on the use of probiotics as adjuncts in periodontal therapy. The review followed the Scale for the Assessment of Narrative Review Articles criteria, applied exclusively as a reporting-quality framework. A literature search was conducted in MEDLINE via PubMed for manuscripts indexed through January/2026, using MeSH terms related to periodontitis and probiotics. Probiotics demonstrate potential as adjunctive agents in periodontal therapy, as evidenced by improvements in clinical parameters (probing depth, clinical attachment level, and/or bleeding on probing) reported in clinical studies. However, the findings remain heterogeneous across trials. Variability in probiotic strains, CFU concentrations, administration routes, and treatment durations highlights the need for standardized clinical protocols to improve comparability and reproducibility and better establish their clinical efficacy. Stronger, long-term evidence is required to standardize therapeutic protocols. Full article
(This article belongs to the Special Issue Periodontal Therapy: Latest Advances and Prospects)
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19 pages, 1893 KB  
Review
Associations Between Lifestyle, Habits, Quality of Life and Non-Carious Diseases: A Scoping Review
by Rodrigo Silveira Tosta Figueiredo, Luiz Renato Paranhos, Gabriela Melo Terra Palazzo, Gustavo Henrick Ferreira Mendonça, Eduarda Betiati Menegazzo, Paulo Vinícius Soares and Jaqueline Vilela Bulgareli
Appl. Sci. 2025, 15(24), 13265; https://doi.org/10.3390/app152413265 - 18 Dec 2025
Viewed by 775
Abstract
This scoping review aimed to map and synthesize the scientific evidence on how lifestyle factors and quality of life are associated with the onset and progression of non-carious diseases (NCDs) in young and adult populations, identifying patterns, methodological characteristics, and gaps in the [...] Read more.
This scoping review aimed to map and synthesize the scientific evidence on how lifestyle factors and quality of life are associated with the onset and progression of non-carious diseases (NCDs) in young and adult populations, identifying patterns, methodological characteristics, and gaps in the existing literature. A systematic literature search was conducted across PubMed, Embase, Scopus, and Web of Science databases to retrieve studies evaluating the influence of lifestyle habits and quality of life indicators on NCDs development and worsening. Most included studies were conducted in Brazil, with cross-sectional designs being the most prevalent. The main modulating factors identified included gastroesophageal reflux, post-bariatric conditions, smoking, bruxism, and anxiety. The results were summarized through a descriptive narrative synthesis. Considerable methodological heterogeneity was observed, particularly due to the absence of standardized protocols for NCDs assessment. Methodological quality was also evaluated to contextualize the robustness of the available evidence. Overall, lifestyle and quality of life factors play an important role in the progression of NCDs, underscoring the need for their integration into diagnostic and therapeutic planning. Further clinical studies are warranted to deepen the understanding of the relationship between NCDs and broader health domains, with particular attention to early oral aging syndrome (EOAS). Full article
(This article belongs to the Special Issue Periodontal Therapy: Latest Advances and Prospects)
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