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New Advances in Antioxidants: Properties and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1020

Special Issue Editors


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Guest Editor
Dental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania
Interests: oral health care; periodontology; oral cancer; plant extracts; antioxidants

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Guest Editor
Physiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj Napoca, Romania
Interests: the photochemopreventive effect of natural compounds and nanomaterials phyto-reduced with natural extracts in skin tumors; the anti-inflammatory and anti-proliferative effect of gold and silver nanoparticles and signaling pathways involved in oral carcinogenesis; cytotoxicity of synthetic compounds and natural extracts on fibroblasts and stem cells from the dental follicle; photodynamic therapy in experimental tumors
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Special Issue Information

Dear Colleagues,

In the context of a globally maintained or even increased incidence of oral diseases, alternatives that improve upon the classical methods for addressing oral pathology are emerging.

Modern research directions involve the use of natural bioactive extracts with antioxidant, anti-inflammatory, antimicrobial, antiviral, antitumoral and immunostimulatory effects and other therapeutic properties in the management of a variety of pathologies. Additionally, nanotechnology and the use of bio-nanomaterials for the treatment of oral diseases, especially oral cancer, are becoming attractive method tools for prevention and therapy.

This Special Issue will be dedicated to new advances in the use of antioxidants.

Subjects that will be discussed in this Special Issue will focus on the potential beneficial effects of new/various vegetal extracts with emphasis on their antioxidant properties as well as on optimized biotechnologies for incorporating natural compounds in different delivery forms, including bio-nanomaterials, to improve their bioavailability and therapeutic effects on oral pathology.

All original articles, clinical studies, case reports, case series, and review articles are welcome for submission.

Dr. Scrobota Ioana
Prof. Dr. Adriana Gabriela Filip
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • antioxidants
  • nanomaterials with natural extracts
  • nanotechnology
  • oral pathology
  • clinical dentistry
  • periodontics
  • oral cancer
  • oral biology
  • pharmaceutical research

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Published Papers (1 paper)

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Research

11 pages, 2053 KiB  
Article
The Role of miR-146a in the Anti-Inflammatory and Antioxidant Effects of Shikonin on Gingival Fibroblasts
by Chihiro Fumimoto, Nobuhiro Yamauchi, Kazutaka Imai, Yurika Nakamura, Hitoshi Azuma, Hirohito Kato, Yoichiro Taguchi and Makoto Umeda
Appl. Sci. 2025, 15(4), 2019; https://doi.org/10.3390/app15042019 - 14 Feb 2025
Viewed by 529
Abstract
Shikonin is a naturally occurring compound known for its anti-inflammatory properties and wound-healing effects. The increased production of reactive oxygen species (ROS) causes oxidative stress and influences the progression of periodontal disease. MiR-146a, a type of microRNA, is reported to be involved in [...] Read more.
Shikonin is a naturally occurring compound known for its anti-inflammatory properties and wound-healing effects. The increased production of reactive oxygen species (ROS) causes oxidative stress and influences the progression of periodontal disease. MiR-146a, a type of microRNA, is reported to be involved in the control of inflammation. This research seeks to examine the anti-inflammatory and antioxidant properties of shikonin on human gingival fibroblasts (hGFs) under inflammation induced by Interleukin (IL)-1β, which is associated with the progression of periodontitis and to further investigate the effect of shikonin on miR-146a expression. Cell proliferation, scratching, and toxicity tests were performed, and the shikonin concentration was set at 0.1 µM. The levels of ROS, miR-146a, and inflammatory cytokines were measured to examine the effects of shikonin on inflammation. The addition of shikonin reduced IL-6 by approximately 20% and reduced IL-8 by approximately 30% compared to IL-6 and IL-8 production and expression induced by IL-1β. MiR-146a expression increased 3.38-fold under IL-1β-induced inflammation but showed a decreasing trend with the addition of shikonin. These results suggest that IL-1β-induced inflammation and oxidative stress are regulated by shikonin in hGFs and are associated with the expression of miR-146a. Full article
(This article belongs to the Special Issue New Advances in Antioxidants: Properties and Applications)
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