Microalgae FoodOmics and FeedOmics: Antioxidant Enrichment, ROS Modulation, and Health-Boosting Applications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1301

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Salerno, Salerno, Italy
Interests: drug delivery systems for pharmaceutical; nutraceutical and cosmetic applications; application of micro/nano-encapsulation techniques in particle engineering; biopolymers; medicinal plant extracts; spray drying; technological and solid state characterization
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Special Issue Information

Dear Colleagues,

The Special Issue “Microalgae FoodOmics and FeedOmics: Antioxidant Enrichment, ROS Modulation, and Health-Boosting Applications” addresses the challenges and opportunities associated with utilizing microalgae as bioactive and antioxidant food for human consumption and feed for aquaculture. Enhancing the use of microalgae to improve health outcomes aims to contribute to the development of eco-friendly solutions that align with sustainability goals.

Significant progress has been made in recent years in exploring the potential of microalgae-derived metabolites for aquaculture or human food. Antioxidants metabolites from microalgae, including carotenoids, fatty acids, phytohormones, carbohydrates, vitamins, peptides, and polyphenols, are of considerable interest for healthcare applications.

This Special Issue seeks contributions on how microalgae biomass and compounds affect animal fitness or human wellness through in vitro or in vivo approaches, focusing on metabolic pathways related to cellular responses to microalgae-derived antioxidants. We welcome studies involving genomics, transcriptomics, proteomics, and metabolomics as well as microalgae antioxidant biosynthesis, and metabolism.

This Special issue highlights advanced delivery systems, such as encapsulation and carrier-based formulations, that enhance the stability, bioavailability, and targeted release of microalgae-derived bioactives. It aims to present recent advancements and encourages the submission of original research and review articles on promoting microalgae biotechnology for health, focusing on their benefits, mechanisms, and future perspectives.

Dr. Clementina Sansone
Dr. Francesca Sansone
Guest Editors

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Keywords

  • microalgae
  • bioactive compounds
  • antioxidants
  • antioxidant metabolism
  • antioxidant biosynthesis
  • omics
  • vitamins
  • probiotics
  • prebiotics
  • postbiotics
  • drug delivery
  • signal transduction
  • gut/brain axis

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Published Papers (1 paper)

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Research

25 pages, 1868 KB  
Article
The Diatom Odontella aurita Modulates Melanogenesis in B16-F0 Cell Line
by Clementina Sansone, Luigi Pistelli, Debora Paris, Annabella Tramice, Annalaura Iodice and Christophe Brunet
Antioxidants 2025, 14(12), 1402; https://doi.org/10.3390/antiox14121402 - 25 Nov 2025
Cited by 1 | Viewed by 260
Abstract
Melanin, a pigment synthesized by melanocytes, serves as the primary defense against UV-induced skin damage due to its potent antioxidant properties. There is increasing interest in natural substances capable of modulating the melanogenic pathway, particularly in hypopigmentation disorders. This study investigated the effect [...] Read more.
Melanin, a pigment synthesized by melanocytes, serves as the primary defense against UV-induced skin damage due to its potent antioxidant properties. There is increasing interest in natural substances capable of modulating the melanogenic pathway, particularly in hypopigmentation disorders. This study investigated the effect of methanolic extracts from the diatom Odontella aurita—authorized as a food supplement in the EU—on melanogenesis in the B16-F0 murine melanoma cell line. The research evaluated melanin content, tyrosinase activity, and the expression of melanogenesis-related genes and proteins at defined time points. Metabolomic and biochemical analyses were performed to characterize the extract’s composition. Treatment with O. aurita extract significantly increased melanin content in B16-F0 cells by 45% (p < 0.01) compared to control. Tyrosinase activity was elevated by 38% after 24 h (p < 0.01), with gene and protein expression analyses confirming upregulation of Tyrosinase (TYR) after 0.5 h, Tyrosinase Related Protein-1 (TRP1) after 1 h, and Tyrosinase Related Protein-2 (TRP2) after 8 h. The extract also enhanced the cellular antioxidant environment, as evidenced by increased levels of metabolic cofactors and pigment-precursor amino acids. O. aurita methanolic extract accelerates and sustains melanin synthesis and tyrosinase activity, distinguishing its effect from single-compound inducers. These findings support the therapeutic potential of O. aurita for pigmentary disorders and skin health. Further studies should investigate its efficacy and safety in vivo and explore its application in cosmeceutical and nutraceutical formulations. Full article
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