From Marine Organisms to High Value Products with Health Benefits

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 5386

Special Issue Editors


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Guest Editor
Stazione Zoologica Anton Dohrn, sede Molosiglio, via Acton 55, 80133 Naples, Italy
Interests: photosynthesis; microalgae; bioactive molecules; biotechnology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: marine biotechnology; drug discovery; cell biology; pharmaceuticals; nutraceuticals and cosmetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Seas and oceans cover a plethora of habitats, from the less known and exploited (e.g., deep seas) to easier to reach systems, such as coastal areas. The richness of diversity within and among these systems is huge and is related to intrinsic environmental properties as well as the variable frequency of environmental influences. Organisms in these systems have developed a series of biological and/or ecological adaptations to survive and grow. The behavioural, physiological, biochemical and molecular responses invoked by adaptation magnify not only biodiversity but also chemodiversity (chemical diversity mainly associated with secondary metabolites). Marine biodiversity (and chemodiversity) can thus become a fertile platform to be used and developed for human society. In particular, chemodiversity is a valuable source of new natural compounds with useful bioactivities for human, animal and environmental health. Consequently, marine (blue) biotechnology investigation is considered an innovative and productive field of research that allows us to respond to societal requirements for new products and eco-friendly solutions to protect human health and improve human wellness.

For this Special Issue of Antioxidants, “From marine organisms to high value products with health benefits”, we aim to present the latest knowledge on the use of marine biology and biodiversity for the provision of valuable products for biotechnological and societal applications. Biotechnological applications of marine organisms cover different fields, such as nutraceuticals, cosmeceuticals, pharmaceuticals and animal feeding. Original research papers and review articles on these different areas are welcome, and we aim to include research ranging from from marine bacteria, fungi and algae to plants and invertebrates. In particular, we hope to (i) present the on-going research on these organisms as resources for biotechnological applications; (ii) combine and discuss the different approaches carried out; and (iii) present state-of-the-art blue biotechnology challenges as well as struggles to reach related objectives.

Dr. Christophe Brunet
Dr. Clementina Sansone
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungi
  • marine microorganisms
  • marine algae
  • marine invertebrates
  • blue biotechnology
  • antioxidant activity

Published Papers (1 paper)

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Research

13 pages, 2532 KiB  
Article
Engineering the Unicellular Alga Phaeodactylum tricornutum for Enhancing Carotenoid Production
by Francesco Manfellotto, Giulio Rocco Stella, Angela Falciatore, Christophe Brunet and Maria Immacolata Ferrante
Antioxidants 2020, 9(8), 757; https://doi.org/10.3390/antiox9080757 - 16 Aug 2020
Cited by 33 | Viewed by 4950
Abstract
Microalgae represent a promising resource for the production of beneficial natural compounds due to their richness in secondary metabolites and easy cultivation. Carotenoids feature among distinctive compounds of many microalgae, including diatoms, which owe their golden color to the xanthophyll fucoxanthin. Carotenoids have [...] Read more.
Microalgae represent a promising resource for the production of beneficial natural compounds due to their richness in secondary metabolites and easy cultivation. Carotenoids feature among distinctive compounds of many microalgae, including diatoms, which owe their golden color to the xanthophyll fucoxanthin. Carotenoids have antioxidant, anti-obesity and anti-inflammatory properties, and there is a considerable market demand for these compounds. Here, with the aim to increase the carotenoid content in the model diatom Phaeodactylum tricornutum, we exploited genetic transformation to overexpress genes involved in the carotenoid biosynthetic pathway. We produced transgenic lines over-expressing simultaneously one, two or three carotenoid biosynthetic genes, and evaluated changes in pigment content with high-performance liquid chromatography. Two triple transformants over-expressing the genes Violaxanthin de-epoxidase (Vde), Vde-related (Vdr) and Zeaxanthin epoxidase 3 (Zep3) showed an accumulation of carotenoids, with an increase in the fucoxanthin content up to four fold. Vde, Vdr and Zep3 mRNA and protein levels in the triple transformants were coherently increased. The exact role of these enzymes in the diatom carotenoid biosynthetic pathway is not completely elucidated nevertheless our strategy successfully modulated the carotenoid metabolism leading to an accumulation of valuable compounds, leading the way toward improved utilization of microalgae in the field of antioxidants. Full article
(This article belongs to the Special Issue From Marine Organisms to High Value Products with Health Benefits)
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