Dialysis-Induced Oxidative Stress, MicroRNAs and Organ Damage: From Bench to Bedside

Dear Colleagues, 

Dialysis is a life-sustaining therapy for patients with end-stage kidney disease, yet it is associated with persistent oxidative stress and inflammation, which contribute to vascular, cardiac, and multiorgan damage. In recent years, microRNAs (miRNAs) have emerged as crucial post-transcriptional regulators of redox balance, endothelial dysfunction, fibrosis, and immune responses. Altered miRNA profiles in dialysis patients are increasingly recognized as promising biomarkers of oxidative stress and potential therapeutic targets. However, important gaps remain regarding their precise mechanistic roles, diagnostic utility, and how different dialysis modalities modulate miRNA networks and organ injury. 

This Special Issue aims to bring together cutting-edge experimental and clinical research on dialysis-induced oxidative stress, miRNAs, and organ damage. Original research articles and reviews addressing mechanistic pathways, circulating and tissue miRNAs as biomarkers, and innovative miRNA-targeted or antioxidant strategies are welcome. Clinical and translational studies exploring the impact of dialysis techniques, membrane characteristics, and adjuvant therapies on oxidative stress, miRNA expression, imaging findings, and patient outcomes are particularly encouraged.

Dr. Yuri Battaglia
Guest Editor

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