Special Issue "The Role of Peroxiredoxins in Antioxidant Defense and Redox Signaling"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 249

Special Issue Editor

Dr. Armindo Salvador
E-Mail Website
Guest Editor
Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Interests: molecular systems biology; computational biology; redox signaling; oxidative stress; design principles of biomolecular reaction networks

Special Issue Information

Dear Colleagues,

Peroxiredoxins have emerged as key players in multiple facets of antioxidant protection and redox signaling, with important implications for human health. Recent research has highlighted their roles in a wide range of physiological and pathological processes, such as tumor progression and resistance, inflammation, aging, apoptosis, circadian metabolic rhythmicity, mitosis, spindle assembly, and DNA replication fidelity. However, numerous questions about their mechanisms of action and how these relate to structural features remain open. To name but a few: What structural features determine peroxiredoxin's catalytic efficiency and hyperoxidation resistance? What determines the specificity of their interactions with their numerous interactors? How is their activity regulated by covalent modifications, and what is the role of this regulation in the physiological context? Are redox relays the paradigmatic mechanism for transducing hydrogen peroxide signals? Does the operation of peroxiredoxin-mediated redox relays require scaffold proteins, and why? How do peroxiredoxins influence cells’ resistance to hydrogen peroxide? What determines their beneficial versus deleterious effects on cancer?

This Special Issue will welcome reviews and original research articles addressing these and other exciting questions regarding peroxiredoxin’s structural, biophysical, and kinetic properties, novel specific inhibitors and research methods, their mechanisms of action in vivo, and their role in human health.

Dr. Armindo Salvador
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • peroxiredoxins
  • thiol redox systems
  • redox signaling
  • antioxidant protection
  • hydrogen peroxide
  • redox relays
  • redox biology
  • holdases
  • redox medicine
  • oxidative stress

Published Papers

This special issue is now open for submission.
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