Next Article in Journal
Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease
Next Article in Special Issue
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis
Previous Article in Journal
Determination of Three Main Chlorogenic Acids in Water Extracts of Coffee Leaves by Liquid Chromatography Coupled to an Electrochemical Detector
Open AccessArticle

Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes

1
Sports Institute of Finland, 19100 Vierumäki, Finland
2
Department of Health and Exercise and Paavo Nurmi Center, University of Turku, 20540 Turku, Finland
3
Research of Internal Medicine, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, 90220 Oulu, Finland
4
Cardiovascular Research Group, Division of Cardiology, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
5
The UKK Institute for Health Promotion Research, 33500 Tampere, Finland
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(10), 144; https://doi.org/10.3390/antiox7100144
Received: 19 August 2018 / Revised: 18 September 2018 / Accepted: 12 October 2018 / Published: 16 October 2018
(This article belongs to the Special Issue Oxidized LDL Lipids)
We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on the determination of baseline conjugated dienes in lipoprotein lipids. In order to study the effect of an exercise load on ox-LDL and ox-HDL lipids patients in both CAD and CAD + T2D intervention, groups were divided in three based on exercise load (high, medium, and low). During the two-year home-based exercise training program, the study showed that only higher training volume resulted in a decreased concentration of ox-LDL, while the two groups with lower training volumes showed no change. This result indicates that the training load needs to be sufficiently high in order to decrease the concentration of atherogenic ox-LDL lipids in patients with CAD and CAD + T2D. Interestingly, the concentration of ox-HDL did not change in any of the subgroups. This could indicate that the lipid peroxide-transporting capacity of HDL, suggested by results from exercise training studies in healthy adults, may not function similarly in CAD patients with or without T2D. Moreover, the lipid-lowering medication used may have had an influence on these results. View Full-Text
Keywords: exercise; oxidized LDL lipids; oxidized HDL lipids; serum lipids exercise; oxidized LDL lipids; oxidized HDL lipids; serum lipids
Show Figures

Figure 1

MDPI and ACS Style

Tiainen, S.; Kiviniemi, A.; Hautala, A.; Huikuri, H.; Ukkola, O.; Tokola, K.; Tulppo, M.; Vasankari, T. Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes. Antioxidants 2018, 7, 144.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop