Bioactivity Mechanisms of Antioxidant Compounds from Natural Products
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 821
Editor
Interests: bioactive compounds; food chemistry; food technology; plant-based raw materials; food processing; phenolic compounds; antioxidant, anti-inflammatory and anticancer activity; food component interactions; bioavailability; encapsulation; spray drying; freeze-drying; food waste valorization; functional foods; nutraceuticals; biodegradable packaging; cosmetic and biomedical applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural antioxidants are a diverse group of compounds found in plants and foods, as well as in products formed during food processing. This group includes polyphenols, carotenoids, tocopherols, coumarins, terpenoids, and bioactive peptides. There is growing evidence that these molecules have biological effects that extend beyond direct radical scavenging. In particular, they may modulate redox homeostasis, inflammatory responses, cellular signaling, and metabolic pathways. These activities are highly relevant to the prevention and management of chronic diseases associated with oxidative stress, such as cardiovascular disease, cancer, diabetes, and neurodegenerative disorders.
Despite substantial progress in characterizing natural antioxidants, their precise mechanisms of action are not fully understood. Their biological efficacy depends on multiple factors, including chemical structure, molecular form, bioavailability, absorption, metabolism, tissue distribution, and interactions with the food matrix and gut microbiota. Therefore, a deeper understanding of these factors is essential to clarify the health-promoting potential of antioxidant compounds from natural sources.
This Special Issue aims to compile original research articles and review papers focusing on the bioactivity mechanisms of natural antioxidants. Topics of interest include molecular and cellular targets, structure–activity relationships, and various bioactive effects, as well as pharmacokinetics and metabolism. In vitro and in vivo studies relevant to human health are also welcome. Particular attention will be given to contributions that elucidate the molecular and cellular mechanisms underlying the biological activity of natural antioxidants, including the relationships between structural characteristics, chemical composition, bioavailability, and mode of action.
Dr. Joanna Oracz
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural antioxidants
- molecular mechanisms
- bioavailability
- pharmacokinetics
- structure–activity relationships
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