Lipoprotein Function, Oxidative Stress, and Residual Vascular Risk in Cardiovascular Disease: Novel Mechanisms and Therapeutic Targets
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 May 2027 | Viewed by 9
Editors
Interests: clinical biochemistry; atherosclerosis and atherothrombosis; lipid and lipoprotein metabolism; HDL functionality; LDL, oxLDL, and sdLDL; lipoprotein(a) and oxidized phospholipids; triglyceride-rich lipoproteins and remnants; inflammation; platelet activation; natural and synthetic bioactive compounds with atheroprotective properties
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD), driven primarily by atherosclerotic cardiovascular disease (ASCVD), remains a leading cause of global mortality despite current intensive lipid-lowering and anti-inflammatory therapies. This persistent residual vascular risk underscores the complex interplay between lipoprotein qualitative alterations, oxidative stress, and ongoing vascular inflammation. As such, oxidized phospholipids (oxPL) and dysfunctional lipoproteins—including modified LDL, Lp(a), dysfunctional HDL, and triglyceride-rich lipoproteins (TRLs) and their remnants—act as key mediators of endothelial damage, immunothrombosis, and plaque instability.
This Special Issue aims to provide a comprehensive overview of novel pathophysiological mechanisms, clinical biomarkers, and innovative therapeutic strategies aimed at mitigating lipoprotein dysfunction and oxidative vascular damage. We invite original research articles and state-of-the-art reviews addressing, but not limited to:
- Vascular inflammation, endothelial dysfunction, platelet activation, and immunothrombosis in atherogenesis;
- Mechanisms linking oxPL, oxidative stress, and lipoprotein dysfunction to atherothrombosis;
- Novel biomarkers for residual cardiovascular risk assessment;
- Therapeutic interventions, including novel synthetic compounds, biological agents, and natural bioactives, that are targeting vascular redox state and lipid metabolism.
We look forward to your contributions.
Dr. Constantinos C. Tellis
Dr. Christos V. Rizos
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- atherosclerotic cardiovascular disease (ASCVD)
- lipoproteins (LDL, Lp(a), HDL, TRLs and remnants)
- oxidized phospholipids (oxPL)
- vascular inflammation and immunothrombosis
- novel therapeutic targets
- natural and synthetic bioactive compounds
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
