Oxidative Stress and Redox Signaling in Kidney Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 22
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oxidative stress is a critical factor in both physiological homeostasis and the pathogenesis of kidney diseases and the common comorbidities in chronic kidney disease (CKD). It influences cellular defense mechanisms while also driving injury and progression in various renal disorders and common comorbidities of CKD. This Special Issue, "Oxidative Stress and Redox Signaling in Kidney Diseases," seeks to elucidate the dual role of oxidative stress and redox signaling in kidney health and disease, exploring molecular mechanisms, biomarkers, and potential therapeutic strategies.
We invite submissions that investigate the impact of oxidative stress and redox imbalance on kidney function and disease progression. Topics of interest include, but are not limited to, the following:
- Mechanisms of Oxidative Damage: Studies on how reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to cellular and tissue injury in acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy, glomerulonephritis, renal fibrosis, and common comorbidities of CKD such as diabetes, hypertension, and metabolic cardiovascular disease.
- Redox Signaling Pathways: Research into how redox-sensitive signaling molecules regulate renal inflammation, fibrosis, apoptosis, and repair processes.
- Antioxidant Defense Systems: Investigations into endogenous antioxidant mechanisms and the therapeutic potential of targeting redox balance in kidney diseases.
- Inflammation and Oxidative Stress: The interplay between oxidative stress, immune responses, and inflammatory pathways in the progression of renal pathologies and common comorbidities of CKD.
- Biomarkers of Oxidative Stress: Identification and validation of oxidative stress-related biomarkers for early diagnosis, prognosis, and monitoring of kidney diseases.
- Therapeutic Interventions: Development and evaluation of novel antioxidants, redox-modulating agents, and pharmacological approaches to mitigate oxidative damage in renal disorders and common comorbidities of CKD.
- Environmental and Metabolic Influences: The role of external factors, such as toxins, medications (e.g., chemotherapy or nephrotoxic drugs), metabolic disorders (e.g., diabetes and hypertension), anemia, mineral and bone disorders, malnutrition, and lifestyle factors (e.g., diet and exercise) in modulating oxidative stress in the kidneys.
We welcome original research articles, reviews, and clinical studies that advance our understanding of oxidative stress and redox signaling in kidney diseases. This Special Issue aims to provide a platform for innovative research that may lead to improved diagnostic tools and therapeutic strategies for preserving kidney function and enhancing patient outcomes. By fostering interdisciplinary collaboration, we hope to uncover new insights into redox biology in renal health and disease, paving the way for targeted interventions to combat kidney-related oxidative damage.
Prof. Dr. Xiaofeng Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- redox signaling
- kidney diseases
- antioxidant defense
- inflammation
- biomarkers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
