Redox Resilience in Mitochondrial Health and Disease: New Advances in Cellular Defense Mechanisms

Dear Colleagues,

Mitochondria, as the powerhouses of the cell, play a central role in both energy production and cellular homeostasis. Emerging research highlights the crucial role of mitochondrial redox resilience in preserving mitochondrial health, particularly in response to oxidative stress and metabolic challenges. The concept of redox resilience—defined as the capacity of mitochondria to sustain redox homeostasis despite fluctuating environmental and cellular conditions—has profound implications for understanding cellular aging, neurodegenerative diseases, metabolic disorders, and cancer. 

This topic aims to explore the molecular mechanisms underlying mitochondrial redox resilience, focusing on how mitochondria manage oxidative damage, facilitate metabolic reprogramming, and coordinate protective pathways. Investigating mitochondrial redox-sensitive pathways and the interplay between mitochondrial dynamics and cellular stress responses will open new avenues for therapeutic interventions. Additionally, understanding how mitochondrial redox resilience can be harnessed or compromised in disease states offers promising strategies for drug development and precision medicine. We invite contributions from diverse fields, including molecular biology, biochemistry, systems biology, and clinical research, to advance the understanding of mitochondrial redox resilience as a cornerstone of cellular health. This journal will serve as a platform for cutting-edge discussions, fostering novel insights into how mitochondria balance redox homeostasis to preserve cellular physiology and mitigate disease.

Prof. Dr. Yuseok Moon
Dr. Ki Hyung Kim
Guest Editors

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