Type 2 Diabetes and Oxidative Stress and Inflammation: Pathophysiological Mechanisms and Possible Therapeutic Options
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 26878
Special Issue Editors
Interests: medicine; biochemistry; genetics and molecular biology cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
Interests: enzymes activation/deactivation; gene expression; protein levels evaluation
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic disease; organ pathophysiology; cardiovascular disease; metabolomic ad lipidomic technology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Type 2 diabetes (T2D) is the most common chronic metabolic disease. There is strong evidence of interrelationships between oxidative stress and inflammation and molecular and cellular events related to T2D onset, progression, and complications. However, the terms “oxidative stress” and “inflammation” imply a number of different molecular and cellular pathways, regarding, for example, endothelial dysfunction, mitochondrial DNA structure, enzyme activity, and gene expression. Thus, it is clear that a unique, universally applicable biomarker does not exist. Moreover, the significance of a given biomarker might not be the same in the different stages of the disease. Thus, the identification of additional pathways/biomarkers involved in T2D pathophysiology might provide new insights into the onset and development of the disease and its complications, favoring the characterization of new targeted therapeutic approaches for more focused personalized medicine.
In this scenario, additional integrative antioxidant compounds could act as coadjuvants to traditional pharmacological tools, providing more potential therapeutic benefits for the treatment of T2D. However, possible health detrimental effects of antioxidant molecules can also develop.
We invite contributions in the form of both original articles and review manuscripts focusing on the study of oxidative/inflammatory-related mechanisms involved in T2D pathophysiology or discussing biomarkers identification, validation, and implementation and their possible role as targets for therapeutic strategies against T2D. Potential topics include, but are not limited, to:
- known and newly identified oxidative stress/inflammatory-related processes contributing to a better understanding of T2D pathophysiology;
- oxidative/inflammatory biomarkers in T2D: pathophysiological significance and potential utility in the clinical practice towards personalized medicine approaches
- antioxidant therapeutic strategies against T2D
Dr. Cristina Vassalle
Dr. Laura Sabatino
Dr. Melania Gaggini
Dr. Kyriazoula Chatzianagnostou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.