Non-pharmaceutical Antioxidant Agents for Animal and Human Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 4015

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Guest Editor
1. Department of Orthopaedic Surgery, School of Public Health, Johns Hopkins University, Baltimore, MD, USA
2. Department of Molecular Microbiology and Immunology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Interests: in vitro models for disease; tissue repair/regeneration; osteoarthritis; nutraceuticals
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Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are highly reactive molecules that play important roles in cellular functions in animals and humans. When present in excess, ROS are cytotoxic. Under normal physiologic conditions, the levels of these reactive molecules are regulated by the body’s antioxidant system. Oxidative stress results when the production of ROS exceeds the capacity of neutralizing antioxidants to detoxify excess ROS. Oxidative stress has been linked to a wide range of pathophysiological conditions, including inflammatory disorders, joint, cardiovascular, neurological diseases, metabolic disease such as diabetes mellitus, cancer, and aging. Some pharmacologic agents are reported to be efficacious in counteracting the adverse effects of oxidative stress. However, experimental and clinical studies have not provided consistent confirmatory evidence for the antioxidative stress efficacy of these drugs. Scientific interest has turned to non-pharmacologic agents as alternative therapies. This special issue focuses on plant-based agents as candidates to mitigate oxidative stress in aging and disease.

Dr. Carmelita Frondoza
Guest Editor

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Keywords

  • Reactive oxygen species
  • Oxidative stress
  • Plant-derived antioxidants

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Published Papers (1 paper)

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Research

16 pages, 1706 KiB  
Article
Young Shoots of White and Red Headed Cabbages Like Novel Sources of Glucosinolates as Well as Antioxidative Substances
by Joanna Kapusta-Duch and Barbara Kusznierewicz
Antioxidants 2021, 10(8), 1277; https://doi.org/10.3390/antiox10081277 - 12 Aug 2021
Cited by 15 | Viewed by 3171
Abstract
Most literature data indicate that the diet rich in plant products reduces the risk of developing chronic non-communicable diseases and cancer. Brassica vegetables are almost exclusively synthesizing glucosinolates. Glucosinolates are higher in sprouts than in mature plants, being related to the activity of [...] Read more.
Most literature data indicate that the diet rich in plant products reduces the risk of developing chronic non-communicable diseases and cancer. Brassica vegetables are almost exclusively synthesizing glucosinolates. Glucosinolates are higher in sprouts than in mature plants, being related to the activity of the specific myrosinase involved in the degradation of glucosinolates during developmental stages. This study compares the content of total glucosinolates with their profile and, rare in the literature, also with products of their degradation. Average amounts of total glucosinolates in young shoots of white and red headed cabbage were 26.23 µmol/g d.m. and 27.93 µmol/g d.m., respectively. In addition, antioxidative properties of 21-day-old shoots of white and red headed cabbage were assessed. The area of negative peaks after post-column derivatization with the ABTS reagent, indicating antioxidant activity of young red cabbage shoots, was 20185, compared to the value determined for young white cabbage shoots (3929). The results clearly indicate that, regardless of the vegetable species, young shoots of white and red headed cabbage can be an important source of bioactive substances in the diet, thus being an important element of cancer chemoprevention. Full article
(This article belongs to the Special Issue Non-pharmaceutical Antioxidant Agents for Animal and Human Health)
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