Oxidative Stress in Cancers of the Female Reproductive Tract: Bridging Current Knowledge with New Technologies
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 May 2026) | Viewed by 1777
Special Issue Editors
Interests: obstetrics gynecology; gynecologic oncology
Special Issue Information
Dear Colleagues,
Oxidative stress plays a pivotal role in the initiation, progression, and therapeutic response of many cancers, including those affecting the female reproductive tract. Gynecologic malignancies such as cervical, endometrial, ovarian, and uterine sarcomas are influenced by a complex interplay between hormonal, metabolic and inflammatory factors that converge on oxidative and antioxidant pathways. Excessive production of reactive oxygen species (ROS), mitochondrial dysfunction and impaired antioxidant defenses contribute to DNA damage, genomic instability and dysregulation of key signaling pathways driving carcinogenesis. Despite increasing recognition of oxidative stress as a central mechanism in female reproductive cancers, its specific molecular signatures, diagnostic biomarkers and potential as a therapeutic target remain incompletely explored. This Special Issue aims to gather original research and comprehensive reviews addressing the role of oxidative stress and antioxidant mechanisms in the pathogenesis, progression and treatment of female cancers, with the goal of advancing redox-based prevention and therapeutic strategies in women’s health.
Dr. Ioannis A. Kalogiannidis
Guest Editor
Dr. Areti Kourti
Guest Editor Assistant
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Keywords
- oxidative stress
- female reproductive cancers
- reactive oxygen species (ROS)
- antioxidant mechanisms
- therapeutic target
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