Therapeutic Potential of Bioactive Substances in Oxidative Stress-Induced Carcinogenesis

Dear Colleagues,

There is already a consensus that oxidative stress (OS) is not only a result of carcinogenesis but also a significant contributor to its development and progression. The main mechanisms by which OS contributes to carcinogenesis are related to the induction of gene mutations that activate the cell signaling pathways, stimulating cell division and inhibiting apoptosis, promoting angiogenesis, and favoring immune evasion, thereby facilitating the survival and dissemination of tumor cells.

Bioactive substances found in foods and medicinal plants have attracted interest due to their therapeutic potential in cancer prevention and treatment. Studies have demonstrated that antioxidants, such as polyphenols, carotenoids, and vitamins, found in fruits, vegetables, and teas possess protective properties against OS and carcinogenesis. Moreover, bioactive substances in combination with conventional therapies have shown potential effects, increasing treatment efficacy and reducing side effects. Therefore, prospecting substances with therapeutic potential and elucidating their mechanisms of action in the carcinogenesis process may lead to the development of more effective and safer therapeutic strategies.

We invite researchers to propose reviews or original research articles on the latest advances in the study of the therapeutic potential of bioactive substances in OS-induced carcinogenesis that may be included in the following potential topics (but are not limited to them):

• Antioxidant bioactive substances in cancer chemoprevention;
• Antioxidant bioactive substances in cancer chemotherapy;
• Antimutagenic bioactive substances with antioxidant potential;
• Mechanisms of action of bioactive agents in different stages of carcinogenesis;
• Bioactive substances and conventional therapies.

Prof. Dr. Pollyanna Francielli De Oliveira
Guest Editor

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• carcinogenesis
• reactive oxygen species
• free radicals
• oxidative stress
• therapeutics
• bioactive substances
• antioxidants
• dietary supplementation
• chemoprevention
• biomarkers
• DNA damage