Antioxidant Peptides from Marine Organisms: Structural Insights, Functional Mechanisms, and Sustainable Applications

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 1 June 2026 | Viewed by 737

Special Issue Editor


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Guest Editor
National and Provincial Joint Laboratory of Exploration, Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China
Interests: research on comprehensive utilization of marine biological resources and germplasm resources development and utilization and genetic breeding; reproductive biology; developmental biology; reproductive regulation; cephalopods
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Special Issue Information

Dear Colleagues,

In recent years, there have been an increasing number of reports on the preparation, structure, and activity of marine antioxidant peptides. These peptides, derived from the vast biodiversity of marine ecosystems including fish, algae, mollusks, and microorganisms, represent an untapped reservoir of bioactive compounds shaped by evolutionary adaptation to diverse marine environments. New methods and technologies such as computer-aided mathematical models (molecular docking, QSAR studies, etc.), bioinformatics tools, and real-time-updated protein databases have been widely explored and studied for marine antioxidant peptides.

In addition, marine antioxidant peptides not only retain high nutritional value, but also enhance the treatment of oxidation-related diseases, delay the oxidation of food, and thereby improve quality of life. Their structural and functional diversity is intrinsically linked to the genetic and organismic diversity of their marine sources, offering unique opportunities to understand how biodiversity contributes to bioactive compound discovery.

Given the widespread and current interest in this topic, this Special Issue joins Antioxidants and Diversity with the aim of publishing recent research on the following topics of interest:

  • Using new methods and technologies to produce antioxidant peptides from marine proteins;
  • Comprehensive studies of the structure–activity relationship of marine antioxidant peptides;
  • Understanding the antioxidant mechanism and the verification of health benefits in vivo;
  • Exploring the biodiversity basis of marine peptide bioactivity;
  • Sustainable utilization of marine biological resources for peptide discovery.

We particularly encourage studies that reveal the connections between marine biodiversity and peptide bioactivity, as well as research addressing the conservation and sustainable use of marine genetic resources.

You may choose our Joint Special Issue in Diversity.

Prof. Dr. Changfeng Chi
Guest Editor

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Keywords

  • marine peptides
  • antioxidant activity
  • structure identification
  • structural modification
  • bioactivity and function
  • structure
  • function relationship
  • functional foods
  • biodiversity
  • organismic diversity and diversity preservation
  • genetic diversity

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Published Papers (1 paper)

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Review

43 pages, 2456 KB  
Review
Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure–Activity Relationships, and Structural Modifications
by Mohammed S. Qoms, Sok Kuan Wong, Norsyahida Mohd Fauzi, Khairana Husain, Suzana Makpol and Jen Kit Tan
Antioxidants 2025, 14(10), 1170; https://doi.org/10.3390/antiox14101170 - 25 Sep 2025
Viewed by 571
Abstract
Microalgae are an emerging source of bioactive peptides with promising therapeutic potential against lifestyle-related diseases such as oxidative stress-related conditions, hypertension, diabetes, and obesity. While numerous studies have investigated the biological activities of microalgae-derived peptides, a comprehensive understanding of their structural features and [...] Read more.
Microalgae are an emerging source of bioactive peptides with promising therapeutic potential against lifestyle-related diseases such as oxidative stress-related conditions, hypertension, diabetes, and obesity. While numerous studies have investigated the biological activities of microalgae-derived peptides, a comprehensive understanding of their structural features and structure–activity relationships remains limited. This review provides a detailed overview of current strategies used to discover bioactive peptides from microalgae, encompassing both conventional and computational approaches. Particular emphasis is placed on correlating identified peptide sequences with their reported biological activities to provide critical insights into the key structural motifs responsible for activity. Furthermore, recent advances in peptide modification techniques are discussed in the context of enhancing the bioactivity of microalgae-derived peptides. By integrating discovery strategies, structure–activity relationships, and emerging trends in peptide modification, this review highlights the potential of microalgae-derived peptides as next-generation therapeutic agents for managing lifestyle-related diseases and identifies opportunities for future research and clinical translation. Full article
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