Mitochondrial Dysfunction and Oxidative Stress in Aging and Age-Related Disorders

Dear Colleagues,

Aging is a complex, multifactorial process characterized by the progressive accumulation of damage to molecular and cellular structures. This damage drives the onset of cellular senescence, impaired tissue function, and, ultimately, the pathologies associated with advanced age. Among the core hallmarks of aging, mitochondrial dysfunction and oxidative stress are recognized as central players in this decline. The aging process is associated with the accumulation of mitochondrial damage, leading to electron transport chain inefficiency, reduced ATP production, and increased generation of reactive oxygen species (ROS). This creates a vicious cycle of oxidative damage, evident in the accumulation of impaired lipids, proteins, and DNA, which is strongly correlated with age and the progression of numerous age-related diseases.

Mitochondrial failure is intimately linked to the pathogenesis of major disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's, cardiovascular diseases (a leading cause of mortality in the elderly), and metabolic syndrome. Consequently, understanding these mechanisms is a key frontier for research aimed at promoting healthy aging and developing novel therapeutic interventions.

For this Special Issue of Antioxidants, we invite researchers to contribute original research articles and comprehensive reviews that elucidate the role of mitochondrial dysfunction and redox imbalance in aging and age-related disorders. We seek to advance the understanding of these critical drivers and explore strategies to counteract their detrimental effects.

Dr. Dharendra Thapa
Guest Editor

Manuscript Submission Information

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