Mitochondrial Dysfunction and Oxidative Stress in Aging and Age-Related Disorders
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 1730
Special Issue Editor
2. Mitochondria, Metabolism & Bioenergetics Working Group, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
Interests: oxidative stress; mitochondrial dysfunction; age-related diseases; metabolism; cardiovascular diseases; acetylation; diabetes
Special Issue Information
Dear Colleagues,
Aging is a complex, multifactorial process characterized by the progressive accumulation of damage to molecular and cellular structures. This damage drives the onset of cellular senescence, impaired tissue function, and, ultimately, the pathologies associated with advanced age. Among the core hallmarks of aging, mitochondrial dysfunction and oxidative stress are recognized as central players in this decline. The aging process is associated with the accumulation of mitochondrial damage, leading to electron transport chain inefficiency, reduced ATP production, and increased generation of reactive oxygen species (ROS). This creates a vicious cycle of oxidative damage, evident in the accumulation of impaired lipids, proteins, and DNA, which is strongly correlated with age and the progression of numerous age-related diseases.
Mitochondrial failure is intimately linked to the pathogenesis of major disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's, cardiovascular diseases (a leading cause of mortality in the elderly), and metabolic syndrome. Consequently, understanding these mechanisms is a key frontier for research aimed at promoting healthy aging and developing novel therapeutic interventions.
For this Special Issue of Antioxidants, we invite researchers to contribute original research articles and comprehensive reviews that elucidate the role of mitochondrial dysfunction and redox imbalance in aging and age-related disorders. We seek to advance the understanding of these critical drivers and explore strategies to counteract their detrimental effects.
Dr. Dharendra Thapa
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- mitochondrial dysfunction
- oxidative stress
- aging
- age-related diseases
- mitochondrial biogenesis
- reactive oxygen species (ROS)
- mitochondrial quality control
- redox homeostasis
- cellular senescence
- neurodegeneration
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