Novel Antioxidant Mechanisms and Lifestyle Interventions for the Management of Oxidative Stress in Obesity and Related Adverse Health Effects

Dear Colleagues,

Obesity and oxidative stress (OxS) are strictly interconnected and are conceived as a vicious circle. Excessive fat accumulation causes mitochondrial dysfunction, which in turn causes oxidative stress through the overproduction of reactive oxygen species (ROS).

OxS exacerbates obesity by altering fat cells’ plasticity, the mechanism of activation of the hypothalamic satiety center, and worsening chronic inflammation. OxS is a crucial factor that leads to the development of inflammation and subsequent metabolic syndrome. Moreover, ROS overproduction is a major player in the pathophysiology of cardiovascular disease.

Lifestyle plays an important role in promoting or counteracting OxS onset and, consequently, the risk of obesity, diabetes, and cardiovascular disease. While excessive consumption of energy-rich foods and sedentary lifestyle promote OxS, healthy diet and physical exercise are associated with significant reduction in the risk of ROS overproduction. Lifestyle modification and innovative antioxidant strategies represent a promising and effective approach in managing obesity and related comorbidities.

In this Special Issue, we will discuss the latest advances in the knowledge on oxidative stress mechanisms involved in obesity and in obesity-associated comorbidities, and we will analyze preclinical and clinical data focusing on therapies aiming to counteract obesity oxidative stress. 

Prof. Ileana Marina Terruzzi
Dr. Pamela Senesi
Guest Editors

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• Signaling cascade involved in oxidative stress
• Obesity and obesity-correlated comorbidities
• Innovative antioxidant therapies
• Diet interventions
• Physical exercise