Innovative Processing Technologies and Their Effects on Antioxidant Activity in Plant-Derived Natural Products

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1076

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CIMO, LA SusTEC, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Interests: natural products; bioactive compounds; pharmacological activity; cancer chemoresistance; antioxidant and anti-inflammatory mechanisms; drug discovery; functional foods; molecular pharmacology; toxicology; biotechnology; cellular models; human health; sustainable bioproducts
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Special Issue Information

Dear Colleagues,

Extraction methodologies exert a critical influence on the qualitative and quantitative profiles of bioactive compounds in natural extracts. Parameters such as solvent type, polarity, temperature, extraction duration, and pressure directly influence the recovery of bioactive secondary metabolites, including phenolic compounds, alkaloids, terpenoids, and carotenoids. This Special Issue aims to highlight recent advances in the study of how both conventional and innovative extraction methods, such as ultrasound, microwave, and supercritical fluid-assisted extraction, impact the chemical composition, antioxidant activity, and functional potential of natural products. Studies that combine detailed chemical characterization with modern methodological approaches, including cell-based assays and other biologically relevant models, are encouraged, providing a more comprehensive understanding of antioxidant activity. Contributions exploring correlations between extraction conditions, phytochemical profiles, and functional antioxidant responses, as well as approaches to optimize yield, bioactivity, and environmental sustainability, are particularly welcome. This Special Issue invites researchers to contribute original research or review articles on natural compounds from diverse sources, including plants, mushrooms, marine organisms, and bee products. Topics of interest include chemical and biological characterization, extraction and isolation procedures, and the development of innovative applications in nutraceutical, pharmaceutical, food, or cosmetic contexts.

Dr. Filipa Mandim
Guest Editor

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Keywords

  • innovative extraction methodologies
  • natural antioxidants
  • oxidative stress modulations
  • cell-based and biochemical assays

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Published Papers (1 paper)

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Research

17 pages, 645 KB  
Article
Extraction Processing Technologies and Their Effects on Antioxidant Activity in Cinnamomum camphora (L.) J. Presl Leaves
by Myat Pwint Phyu, Yuchen Cheng, Yuri Kang, Hyunjae Jang, Seungwoong Lee and Woonjung Kim
Antioxidants 2026, 15(2), 227; https://doi.org/10.3390/antiox15020227 - 9 Feb 2026
Cited by 1 | Viewed by 768
Abstract
This study investigated the bioactive potential of Cinnamomum camphora (L.) J. Presl (C. camphora) leaf extracts obtained using hydrothermal extraction (HE) and ultrasound-assisted extraction (UAE) with 30%, 50%, and 70% ethanol (v/v). Extracts were analyzed for their [...] Read more.
This study investigated the bioactive potential of Cinnamomum camphora (L.) J. Presl (C. camphora) leaf extracts obtained using hydrothermal extraction (HE) and ultrasound-assisted extraction (UAE) with 30%, 50%, and 70% ethanol (v/v). Extracts were analyzed for their phytochemical composition and biological activities. UAE extracts, particularly with 70% ethanol, exhibited the highest total polyphenol (363.0 ± 1.40 mg GAE/g) and flavonoid (174.5 ± 0.42 mg QE/g) contents. This extract also demonstrated strong antioxidant activities (IC50: 0.024 ± 0.001 mg/mL for DPPH; IC50: 0.363 ± 0.002 mg/mL for ABTS; 3.080 ± 0.044 M Fe2+/g for FRAP) and potent enzyme inhibition (49.3 ± 0.35% for tyrosinase; 24.8 ± 0.34% for elastase; 94.5 ± 0.12% for α-glucosidase and 77.5 ± 1.11% for lipase). Antimicrobial activity was most effective against Gram-positive bacteria, notably against Cutibacterium acnes, showing the largest inhibition zone (23.0 mm at 10 mg/disc). Overall, antioxidant, enzyme inhibition and antimicrobial activities increased significantly with increasing ethanol concentration, particularly at 70% ethanol. GC–MSD analysis revealed that both HE and UAE extracts contained phenolic acids, terpenes, triterpenes, and sesquiterpenes. Collectively, these findings indicate that the extraction method (UAE) and solvent composition (70% ethanol) influence the bioactivity profile of C. camphora leaf extracts, supporting further investigation of their relevance for cosmeceutical and functional applications. Full article
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