Bioactive Compounds and Antioxidants in Fruits and Vegetables—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 633

Special Issue Editors


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Department of Pharmacy-Drug Sciences, University Aldo Moro Bari, 70125 Bari, Italy
Interests: analysis and research methods applied to complex matrices of nutraceutical interest; enhancement of matrices of the Mediterranean diet for the treatment of preschool pediatric obesity; enhancement of matrices of the Mediterranean diet for the treatment of endometriosis; SAR and 3D-QSAR design; synthesis and characterization (GC MS, H NMR, FT) of molecules with potential pharmacological activity; development of advanced methodologies in pharmaceutical analysis; analytical separation of newly synthesized molecules and biomolecules via U-HPLC and HPLC; project-based learning
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Special Issue Information

Dear Colleagues,

The increasing volume of scientific studies highlights the functional and health-promoting properties of bioactive molecules derived from plant matrices and their byproducts. Among these, polyphenols have been extensively investigated for their potential in addressing metabolic disorders, including obesity, dyslipidaemia, hypertension, and blood glucose imbalances, as well as associated complications such as oxidative stress and inflammation. Despite extensive research, establishing a definitive cause-and-effect relationship between polyphenols and their health benefits remains a challenge.

This Special Issue aims to consolidate interdisciplinary expertise in chemistry, pharmacology, biochemistry, drug chemistry, and toxicology. We invite researchers to submit original research articles, clinical studies, and comprehensive reviews that provide deeper insights into the mechanisms by which polyphenols contribute to health benefits.

The goal is to create a scientific foundation that facilitates the translation of findings into practical applications, benefitting consumer health through industrial advancements.

Prof. Dr. Filomena Corbo
Dr. Marilena Muraglia
Guest Editors

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Keywords

  • metabolic syndrome (MetS)
  • multi-target
  • polypharmacology
  • prevention
  • polyphenols
  • antioxidants
  • anti-inflammation
  • ageing
  • cancer
  • cardiovascular diseases
  • diabetes
  • obesity
  • mediterranean diet
  • health claim
  • human studies
  • green extraction
  • metabolomic
  • experimental design
  • nutrition
  • neuropathic pain
  • obesity
  • paediatrics

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Published Papers (1 paper)

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Research

21 pages, 3244 KB  
Article
Influence of Blueberry Mosaic Disease on Polyphenolic Profile and Antioxidant Capacity of Highbush Blueberry ‘Duke’ Fruits
by Nemanja Miletić, Danijel D. Milinčić, Mirjana B. Pešić, Biljana Lončar, Marko Petković, Bojana Vasilijević and Darko Jevremović
Antioxidants 2025, 14(11), 1302; https://doi.org/10.3390/antiox14111302 - 29 Oct 2025
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Abstract
Blueberry mosaic virus (BlMaV) is a persistent pathogen that alters host physiology; however, its impact on secondary metabolism in blueberry fruits remains poorly characterized. In this study, the phenolic profile of the cultivar ‘Duke’ was systematically examined in healthy and BlMaV-infected plants over [...] Read more.
Blueberry mosaic virus (BlMaV) is a persistent pathogen that alters host physiology; however, its impact on secondary metabolism in blueberry fruits remains poorly characterized. In this study, the phenolic profile of the cultivar ‘Duke’ was systematically examined in healthy and BlMaV-infected plants over two successive years. Using UHPLC Q-ToF MS, a total of 46 phenolic compounds were detected, spanning flavonols, phenolic acids, and anthocyanins. Comparative analyses revealed consistent shifts in metabolite abundance between healthy and infected samples. Several flavonol aglycones and phenolic acid derivatives accumulated in infected fruits, whereas multiple anthocyanins and glycosides were reduced. To further explore metabolic relationships, color correlation analysis highlighted distinct co-variation patterns among compound classes. Principal component analysis clearly separated infected and healthy fruits, confirming that viral infection was the dominant source of variation, surpassing the influence of harvest year or environmental factors. Nevertheless, the antioxidant capacity remained unchanged, regardless of the presence of the virus or the variation in environmental conditions. These results provide novel biochemical evidence that BlMaV infection reshapes the phenolic composition of blueberries and lays the groundwork for future studies on the metabolic consequences of viral stress in fruit crops. Full article
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