Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—2nd Edition

Dear Colleagues,

We are delighted to be organizing Volume 2 of this Special Issue, entitled “Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases”, especially given the success of Volume 1, which you can read here:

https://www.mdpi.com/journal/antioxidants/special_issues/JEF308HCNO.

Mitochondria are organelles involved in cellular processes including energy production through the oxidative phosphorylation system and in various critical signaling pathways. Mitochondria are not static entities but are dynamic units that undergo fission and fusion cycles to maintain their structural integrity. They are also the principal site of cellular reactive oxygen species (ROS) production, and an imbalance between the production of ROS and cellular antioxidant defenses leads to alterations to cell homeostasis. It is well known that impaired mitochondrial integrity is associated with the pathogenesis of various metabolic diseases, non-communicable pathologies characterized by inflammatory processes closely related to mitochondrial dysfunction. In recent decades, these organelles have been considered as a target of potential therapeutic approaches for the treatment of various diseases. Moreover, molecules naturally produced by plants and a variety of synthetic compounds are capable of modulating mitochondrial function. This Special Issue aims to collect original research and review articles describing the role of mitochondria in metabolic alterations and the potential therapeutic approaches adopted for improving the impaired functionality of mitochondria. Manuscripts that investigate the influence of the natural or chemical compounds that modulate mitochondrial function and the underlying mechanisms will be considered. This data collection can help redefine preventive and therapeutic strategies in an attempt to prevent and counter the onset of metabolic diseases.

Dr. Gina Cavaliere
Prof. Dr. Maria Pina Mollica
Dr. Giovanna Trinchese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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