Oxidative Stress and Inflammation in Osteoarthritis and Rheumatoid Arthritis

Dear Colleagues,

We invite authors to submit original research papers, reviews, and meta-analyses on the topic of "Oxidative Stress and Inflammation in Osteoarthritis and Rheumatoid Arthritis" for a planned Special Issue.

We are currently witnessing an unprecedented increase in the number of older people in society, with technological and medical advances leading to significant increases in lifespan. This has also led to challenges that have not been previously experienced or that only affected a small number of patients. The aging population poses new challenges for medicine. Among the diseases associated with aging are osteoarthritis (OA) and rheumatoid arthritis (RA). The number of patients with both conditions has increased dramatically over the past 30 years. Traditionally, RA was considered an autoimmune disease, while OA was considered a degenerative joint disease. It is now known that inflammation and oxidative stress are features of both conditions, and reducing them has become a key therapeutic goal.

Oxidative stress and inflammation are key pathogenic mechanisms in OA and RA. In RA, proinflammatory cytokines and chemokines, transcription factors, and reactive oxygen species (ROS) drive autoimmune inflammation in the synovium, while in OA, mechanically induced oxidative stress amplifies cartilage degradation through the activation of metalloproteinases and chondrocyte apoptosis. Complex interactions between NADPH oxidases, the transcriptional activation of proinflammatory genes, and the expression of chemokines (such as CXC and their receptors) create promising therapeutic targets that require further molecular investigation. We invite submissions for studies that include, but are not limited to, the following:

• Molecular mechanisms, such as the activation of proinflammatory gene transcription, the role of ROS in the initiation and propagation of inflammatory responses, etc.;
• Markers of oxidative stress and antioxidant enzyme activity;
• The involvement of cytokines/chemokines in the propagation of inflammatory responses;
• Targeted therapies: the action of antioxidants, inhibitors, and modulators of inflammatory responses, the use of drugs targeting the chemokine system in therapies, etc.;
• Translational studies such as correlations between biomarkers and radiological studies;
• Experimental models such as 3D chondrocyte cultures;
• Studies of antioxidant enzyme gene polymorphisms;
• Research on the impact of lifestyle, including diet/dietary supplements and physical activity, on inflammatory processes and oxidative balance.

This Special Issue will focus on the importance of oxidative stress and inflammation in osteoarthritis and rheumatoid arthritis. We strongly encourage you to submit research papers on topics consistent with the subject matter of the Special Issue.

Dr. Katarzyna Piotrowska
Dr. Mateusz Bosiacki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• proinflammatory gene transcription
• markers of oxidative stress and antioxidant enzyme activity
• targeted therapies in OA and RA
• translational studies
• experimental models including 3D chondrocyte cultures
• antioxidant enzyme gene polymorphisms
• impacts of diet/dietary supplements and physical activity on inflammatory processes and oxidative balance