Research of Small-Molecule Therapeutics in Transplantation and Tolerance
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 7062
Special Issue Editor
Special Issue Information
Dear Colleagues,
Organ transplantation is the best curative treatment for patients with end-stage organ disease. An unavoidable complication leading to early allograft dysfunction is mediated primarily by ischemia-reperfusion injury (IRI). This peri-transplant clinical condition is characterized by interrelated phases involving donor-tissue ischemic necrosis and recipient reperfusion, which introduces the innate-adaptive immune interface that promotes pro- and anti-inflammatory responses. As the consequences of I/R injury remain vast, understanding the mechanistic factors leading to I/R injury remains a top priority. Determining the peak induction potential of the signaling networks that attenuate antioxidant, detoxification, and homeostatic functions may be the key to understanding why specific therapeutic strategies fail to advance through clinical trials.
In the past year, small-molecule therapeutics, comprised of RNA, protein, and/or drug-based molecules, have achieved impressive results regulating gene expression networks involved in pro- and anti-inflammatory responses to organ transplantation injury. They have been shown to significantly increase the capacity to prevent organ rejection by reducing oxidative stress and inflammation, modulating the immune response, and stimulating the production of protective enzymes that promote tissue repair. The aim of this Special Issue is to illustrate how these small molecules hold the potential to improve the survival of patients undergoing solid organ transplantation.
Dr. Kenneth J. Dery
Guest Editor
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Keywords
- organ transplantation
- oxidative stress
- ischemia-reperfusion injury
- short-activating RNA
- small-molecule therapeutics
- early allograft dysfunction
- morpholinos
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