Reactive Oxygen Species in Cancer and Viral Diseases: A Double-Edged Sword
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 151
Editors
Interests: mitochondrial metabolism and function; cancer biology; oxidative stress; lipid metabolism
2. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, Argentina
Interests: virology; veterinary virology; immunology; cell biology; reactive oxygen species
Special Issue Information
Dear Colleagues,
Reactive oxygen species (ROS) are essential byproducts of cellular metabolism that regulate signaling and maintain redox homeostasis. However, excessive accumulation of ROS leads to oxidative stress with several implications in disease. In cancer, elevated ROS—particularly under chemotherapy, radiation or other conditions—can promote tumor cell death and improve therapeutic outcomes. In contrast, in viral infections, excessive ROS often contributes to host cell damage and disease progression, highlighting the context-dependent, double edge-sword behavior of ROS.
Mitochondria are a major source of intracellular ROS formation generated by the flow of electrons through the electron transport chain, linking mitochondrial metabolism to redox balance and disease pathogenesis. Despite important advances in the field, important gaps remain in understanding the mechanisms of oxidative stress, its pathological consequences, and its diagnostic and therapeutic potential.
This Special Issue aims to gather contributions on ROS-related mechanisms in cancer and viral diseases, including effects on macromolecules, signaling pathways, and antioxidant defenses. Both original research and reviews are welcome. By advancing mechanistic insights, this issue seeks to increase our basic knowledge of the role of ROS in pathological conditions and, eventually, support the development of novel therapeutic strategies that either enhance ROS-mediated cytotoxicity in cancer or mitigate oxidative damage in viral infections.
Dr. Eduardo Maldonado
Dr. Sandra Pérez
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- reactive oxygen species (ROS)
- oxidative stress
- mitochondria
- cancer
- viral infections
- redox homeostasis
- antioxidant defenses
- chemotherapy
- electron transport chain
- ROS-mediated cytotoxicity
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