Oxidative Stress and Antioxidant Defense in Ocular Diseases: From Genetics to Emerging Intercellular Mechanisms and Therapeutic Strategies
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2027 | Viewed by 307
Editors
Interests: ocular diseases; oxidative stress; antioxidant defense; redox signaling; exosomes
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; epigenetics; ocular diseases; oxidative stress; antioxidant defense
Special Issue Information
Dear Colleagues,
Oxidative stress is a central pathogenic factor in a wide range of ocular diseases, contributing to cellular dysfunction, inflammation, and progressive tissue degeneration. Due to its high metabolic activity and continuous exposure to light and environmental stressors, the eye is particularly susceptible to redox imbalance, making antioxidant defence mechanisms critical for the maintenance of visual homeostasis. This Special Issue aims to gather original research articles and comprehensive reviews that address the role of oxidative stress and antioxidant responses in major ocular disorders, including age-related macular degeneration, glaucoma, diabetic retinopathy, cataract, and inflammatory eye diseases. Particular emphasis will be placed on genetic and epigenetic factors influencing oxidative stress susceptibility, as well as on emerging intercellular mechanisms such as redox signalling, extracellular vesicle-mediated communication, and interactions among retinal and non-retinal cell types. In addition, this Special Issue seeks to highlight innovative therapeutic strategies, ranging from conventional antioxidant approaches to targeted and novel interventions aimed at modulating redox pathways. By integrating insights from molecular genetics, cell biology, and translational research, this collection intends to provide an updated and comprehensive overview of redox-related mechanisms in ocular diseases and identify promising avenues for future therapeutic development.
Prof. Dr. Marialaura Amadio
Dr. Federico Manai
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- antioxidant defense
- ocular diseases
- redox signaling
- therapeutic strategies
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