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Antibiotics
Special Issues
Antimicrobial Resistance from a One Health Perspective
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Antimicrobial Resistance from a One Health Perspective

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 August 2026 | Viewed by 12029

Special Issue Editor

Dr. Flávia L P. C. Pellegrino

E-Mail Website
Guest Editor
Integrated Research Laboratories on Antimicrobial Resistant Bacteria and Galenic Development (LIPE), Pharmacy Department, Faculty of Biological Sciences and Health (FCBS), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil
Interests: antimicrobial resistant bacteria; bacterial virulence; urinary tract infection; antibiotic use; vaccine; One Health

Special Issue Information

Dear Colleagues,

Bacterial resistance to antimicrobial agents has been widely discussed for decades around the world. Although it is a natural phenomenon and an ancient concept, antimicrobial resistance is considered a current global problem that remains challenging for health professionals in developed or developing countries, such as Brazil.

Excessive prescription and indiscriminate consumption of antibiotics accentuate the problem, contributing to the selection of bacterial pathogens carrying antibiotic resistance genes and expressing resistance to multiple classes of antimicrobial drugs in clinical use.

Resistant bacteria are common as a cause of infections acquired both in the hospital and in the community environment. From a One Health perspective, antimicrobial resistance has a strong negative impact on the health of people and the planet.

In this sense, we invite you to publish in the Special Issue “Antimicrobial Resistance from a One Health Perspective”, raising high-level discussions based on robust scientific results. Research articles and reviews addressing the following will be accepted:

  1. Antimicrobial resistance mechanisms and new therapeutic approaches;
  2. New substances and molecules with antimicrobial action;
  3. Innovation in the detection of the antimicrobial resistance;
  4. Virulence strategies of clinically relevant bacteria;
  5. Clonal diversity and molecular epidemiology of bacterial pathogens;
  6. Urinary tract infection by antimicrobial-resistant bacteria.

Dr. Flávia L P. C. Pellegrino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance mechanisms
  • bacterial virulence
  • clonal diversity
  • molecular epidemiology
  • antibiotic use
  • infectious diseases
  • One Health

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 1515 KB  
Article
Assessment of Antimicrobial Resistance and Virulence of Biofilm-Forming Uropathogenic Escherichia coli from Rio de Janeiro
by Maria Clara F. Oliveira, Anna Luiza B. Canellas, Lidiane C. Berbert, Alexander M. Cardoso, Vitoria A. Silva, Samantha S. T. Garutti, Débora Hosana F. Rangel, Rubens Clayton S. Dias, Jamila Alessandra Perini, Claudia R. V. M. Souza, Thiago P. G. Chagas, Marinella S. Laport and Flávia Lúcia P. C. Pellegrino
Antibiotics 2025, 14(9), 869; https://doi.org/10.3390/antibiotics14090869 - 29 Aug 2025
Cited by 1 | Viewed by 2341
Abstract
Background/Objectives: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in both community and hospital settings worldwide. Antimicrobial-resistant UPEC strains pose a significant challenge for effective antibiotic therapy. In this study, 50 bacterial isolates recovered from urine samples of patients [...] Read more.
Background/Objectives: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in both community and hospital settings worldwide. Antimicrobial-resistant UPEC strains pose a significant challenge for effective antibiotic therapy. In this study, 50 bacterial isolates recovered from urine samples of patients attended in different sectors of a public hospital in Rio de Janeiro over five months were analyzed to assess antimicrobial resistance and virulence profiles through broad gene screening. Methods: Biofilm production was assessed using a semi-quantitative adherence assay. PCR was employed to investigate 27 resistance genes, 6 virulence genes, sequence types (STs), and phylogroups. Susceptibility to 25 antimicrobial agents was determined by disk diffusion testing. Furthermore, the pathogenic potential was evaluated in vivo using the Tenebrio molitor larvae infection model. Results: Most UPEC isolates were moderate or strong biofilm producers (41/50; 82%). The sul1 and sul2 resistance genes were the most frequently detected (58%). Two virulence gene patterns were identified: fyuA, iutA, fimH, cnf1 and fyuA, iutA, fimH (13 isolates; 26%). ST131 and ST73 were the most common sequence types (16% each), and phylogroup B2 was the most prevalent (50%). Thirty isolates (60%) were multidrug-resistant, most of which belonged to phylogroup B2. UPEC exhibited dose-dependent lethality, causing 100% mortality at 2.6 × 108 CFU/mL within 24 h. Conclusions: These findings reinforce the urgent need for surveillance strategies and effective antimicrobial stewardship in clinical practice. Full article
(This article belongs to the Special Issue Antimicrobial Resistance from a One Health Perspective)
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Review

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18 pages, 2565 KB  
Review
Regulation of Antibiotic Use in Livestock: European and International Strategies to Prevent and Control Antimicrobial Resistance and Ensure Animal Welfare
by Michela Maria Dimuccio, Virginia Conforti, Francesco Emanuele Celentano, Elena Circella, Anna Salvaggiulo, Giancarlo Bozzo and Marialaura Corrente
Antibiotics 2026, 15(1), 67; https://doi.org/10.3390/antibiotics15010067 - 8 Jan 2026
Cited by 5 | Viewed by 2145
Abstract
Antimicrobial resistance (AMR) represents a significant global concern, undermining the efficacy of treatments in both human and veterinary medicine. Livestock production plays a major role in the emergence and dissemination of AMR, primarily due to the extensive use of antibiotics for therapeutic, prophylactic, [...] Read more.
Antimicrobial resistance (AMR) represents a significant global concern, undermining the efficacy of treatments in both human and veterinary medicine. Livestock production plays a major role in the emergence and dissemination of AMR, primarily due to the extensive use of antibiotics for therapeutic, prophylactic, and metaphylactic purposes. Addressing this multifaceted issue necessitates a One Health approach. At the international level, regulatory frameworks are predominantly non-binding, relying on soft-law instruments developed by the World Health Organization (WHO), the Food and Agriculture Organization (FAO), and the World Organization for Animal Health (WOAH, formerly OIE), which advocate for harmonized guidelines and national action plans. In contrast, the European Union has implemented binding regulations, including Regulation (EU) 2019/6 and Regulation (EU) 2019/4, which restrict non-essential antimicrobial use (AMU) and reinforce veterinary accountability. Initiatives such as the Farm to Fork Strategy and platforms like ClassyFarm further advance antimicrobial stewardship by integrating animal welfare, sustainability, and access to EU funding. Achieving substantial reductions in AMR within livestock systems requires coordinated, cross-disciplinary, and multi-level governance efforts. The EU model illustrates how enforceable legal frameworks, combined with science-based monitoring and welfare incentives, can facilitate prudent antibiotic use and promote sustainable animal production. This review aims to provide an integrated overview of international and European strategies for regulating antibiotic use in food-producing animals, focusing on how scientific, veterinary and legal perspectives contribute to combating AMR and promoting animal welfare by emphasizing prevention, and a prudent and responsible AMU. Full article
(This article belongs to the Special Issue Antimicrobial Resistance from a One Health Perspective)
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44 pages, 2066 KB  
Review
Tetracyclines in the Modern Era: Global Consumption, Antimicrobial Resistance, Environmental Occurrence, and Degradation Techniques
by Yuliya Semenova, Larissa Makalkina, Natalya Glushkova and Abduzhappar Gaipov
Antibiotics 2025, 14(12), 1183; https://doi.org/10.3390/antibiotics14121183 - 21 Nov 2025
Cited by 9 | Viewed by 6834
Abstract
Tetracyclines are among the oldest classes of antibiotics, with broad activity against Gram-positive and Gram-negative bacteria, as well as Chlamydia, Legionella, Rickettsia, and Mycoplasma species. Widely used in human and veterinary medicine, agriculture, and aquaculture, they represent approximately 10–12% of [...] Read more.
Tetracyclines are among the oldest classes of antibiotics, with broad activity against Gram-positive and Gram-negative bacteria, as well as Chlamydia, Legionella, Rickettsia, and Mycoplasma species. Widely used in human and veterinary medicine, agriculture, and aquaculture, they represent approximately 10–12% of the global antimicrobial market. Extensive use has driven the emergence and spread of antimicrobial resistance, posing ecological and public health risks. However, the full extent of these risks remains unclear due to limited data on tetracycline consumption, environmental occurrence, and resistance patterns across sectors. Recent One Health-oriented strategies have promoted the rational use of tetracyclines in medicine, veterinary practice, and agriculture. To reduce environmental accumulation, various degradation and remediation techniques have been developed, though most remain restricted to laboratory or engineered settings. This narrative review provides a comprehensive overview of global tetracycline consumption; environmental occurrence; distribution and concentration levels; resistance mechanisms and prevalence; and mitigation strategies, including antimicrobial stewardship and degradation approaches. Understanding these aspects is essential for developing evidence-based interventions to minimize the environmental and public health impacts of tetracycline use. Full article
(This article belongs to the Special Issue Antimicrobial Resistance from a One Health Perspective)
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