Antibiotic Use in European Hospitals and Pharmacies

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 8424

Special Issue Editors


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Guest Editor
1. Department of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
2. Department of Dermato-oncology, Semmelweis University, H-1085 Budapest, Hungary
Interests: clinical pharmacy; medication use; antibiotics
Special Issues, Collections and Topics in MDPI journals
1. Clinical Pharmacy Department, Faculty of Pharmacy, University of Szeged, H-6725 Szeged, Hungary
2. Central Pharmacy, Albert Szent- Györgyi Medical Center, University of Szeged, H-6725 Szeged, Hungary
3. Department of Emergency Medicine, Albert Szent.- Györgyi Medical Center, University of Szeged, H-6725 Szeged, Hungary
Interests: drug utilization research regarding antibiotics both ambulatory and hospital settings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Characteristics of AB use in out- and inpatient heath care settings

The prudent use of antibiotics is one of the most important tools in our hands to contain antibacterial resistance (AMR). As the epicenter of AMR is the hospital setting, optimization of inpatient antibiotic use is crucial, while ambulatory antibacterial use is important as the majority of consumption happens in the outpatient setting. Field research on population-level aggregated data and patient-level data is extremely important and can help to identify problematic fields. We ask authors to share their results based on aggregated or patient-level data and send manuscripts to this Special Issue based on the following topics:

  • Introduction and results of hospital AB stewardship or outpatient setting;
  • Treatment of infections caused by multidrug-resistant bacteria at the ICU setting: patient outcomes;
  • Identifying local problems of hospital antibacterial use based on patient-level data;
  • Outpatient consumption—non-prescription use;
  • Rational and irrational prescribing in ambulatory care;
  • Antibacterial prescribing in special populations (elderly, pediatrics, pregnant women, etc.);
  • The impact of the COVID-19 pandemic on national-level antibacterial use;
  • Determinants of prudent antibacterial use.

Dr. Soós Gyöngyvér
Dr. Benkő Ria
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • public health
  • AB stewardship
  • consumption metrics
  • point prevalence study
  • aggregated data
  • patient level data
  • innovative antibacterials

Published Papers (3 papers)

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Research

11 pages, 4931 KiB  
Article
Prescribing Patterns and Variations of Antibiotic Use for Children in Ambulatory Care: A Nationwide Study
by Githa Fungie Galistiani, Ria Benkő, Balázs Babarczy, Renáta Papp, Ágnes Hajdu, Éva Henrietta Szabó, Réka Viola, Erika Papfalvi, Ádám Visnyovszki and Mária Matuz
Antibiotics 2022, 11(2), 189; https://doi.org/10.3390/antibiotics11020189 - 31 Jan 2022
Cited by 1 | Viewed by 2986
Abstract
The aim of this study was to analyse characteristics of paediatric antibiotic use in ambulatory care in Hungary. Data on antibiotics for systemic use dispensed to children (0–19 years) were retrieved from the National Health Insurance Fund. Prescribers were categorised by age and [...] Read more.
The aim of this study was to analyse characteristics of paediatric antibiotic use in ambulatory care in Hungary. Data on antibiotics for systemic use dispensed to children (0–19 years) were retrieved from the National Health Insurance Fund. Prescribers were categorised by age and specialty. Antibiotic use was expressed as the number of prescriptions/100 children/year or month. For quality assessment, the broad per narrow (B/N) ratio was calculated as defined by the European Surveillance of Antimicrobial Consumption (ESAC) network. Paediatric antibiotic exposure was 108.28 antibiotic prescriptions/100 children/year and was the highest in the age group 0–4 years. Sex differences had heterogenous patterns across age groups. The majority of prescriptions were issued by primary care paediatricians (PCP). The use of broad-spectrum agents dominated, co-amoxiclav alone being responsible for almost one-third of paediatric antibiotic use. Elderly physicians tended to prescribe less broad-spectrum agents. Seasonal variation was found to be substantial: antibiotic prescribing peaked in January with 16.6 prescriptions/100 children/month, while it was the lowest in July with 4 prescriptions/100 children/month. Regional variation was prominent with an increasing west to east gradient (max: 175.6, min: 63.8 prescriptions/100 children/year). The identified characteristics of paediatric antibiotic use suggest that prescribing practice should be improved. Full article
(This article belongs to the Special Issue Antibiotic Use in European Hospitals and Pharmacies)
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12 pages, 561 KiB  
Article
The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit
by Adina Fésüs, Ria Benkő, Mária Matuz, Orsolya Kungler-Gorácz, Márton Á. Fésüs, Tamás Bazsó, Zoltán Csernátony and Gábor Kardos
Antibiotics 2021, 10(12), 1509; https://doi.org/10.3390/antibiotics10121509 - 9 Dec 2021
Cited by 4 | Viewed by 2625
Abstract
Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. The purpose of this study was to analyze the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. The study was conducted [...] Read more.
Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. The purpose of this study was to analyze the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. The study was conducted at an Orthopedic Department of a tertiary care medical center. SAP compliance and antibiotic exposure in the pre-intervention and intervention period was compared using chi-square, Fisher exact, and Mann-Whitney tests, as appropriate. Prophylactic antibiotic use in orthopedic joint arthroplasties (overall guideline adherence: agent, dose, frequency, duration), clinical outcomes (length of stay-LOS, number of surgical site infections-SSIs), antibiotic exposure and direct antibiotic costs were compared between pre-intervention and intervention periods. Significant improvement in mean SAP duration (by 42.9%, 4.08 ± 2.08 vs. 2.08 ± 1.90 days, p ˂ 0.001), and overall guideline adherence regarding antibiotic use (by 56.2%, from 2% to 58.2%, p ˂ 0.001) were observed. A significant decrease was observed in antibiotic exposure in SAP (by 41%, from 6.07 ± 0.05 to 3.58 ± 4.33 DDD/patient, p ˂ 0.001), average prophylactic antibiotic cost (by 54.8%, 9278.79 ± 6094.29 vs. 3598.16 ± 3354.55 HUF/patient), and mean LOS (by 37.2%, from 11.22 ± 6.96 to 7.62 ± 3.02 days, p < 0.001); and a slight decrease in the number of confirmed SSIs was found between the two periods (by 1.8%, from 3% to 1.2%, p = 0.21). Continuous presence of the clinical pharmacist led to significant improvement in SAP guideline adherence, which was accompanied by decreased antibiotic exposure and cost. Full article
(This article belongs to the Special Issue Antibiotic Use in European Hospitals and Pharmacies)
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13 pages, 3217 KiB  
Article
Consumption of Antibacterials for Systemic Use in Slovakia: A National Study and the Quality Indicators for Outpatient Antibiotic Use
by Tomas Tesar, Lucia Masarykova, Lubica Lehocka, Slavka Porubcova, Monika Cicova and Martin Wawruch
Antibiotics 2021, 10(10), 1180; https://doi.org/10.3390/antibiotics10101180 - 28 Sep 2021
Cited by 2 | Viewed by 2241
Abstract
This paper aims to analyse the consumption of antibiotics in the Slovak health care system from 2011 to 2020. The data source on the consumption of antibiotics is sales data from SUKL and NCZI. The study employed the ATC/DDD Index and focused on [...] Read more.
This paper aims to analyse the consumption of antibiotics in the Slovak health care system from 2011 to 2020. The data source on the consumption of antibiotics is sales data from SUKL and NCZI. The study employed the ATC/DDD Index and focused on the consumption of antibiotics in the primary care sector. Total antibiotic consumption decreased from 19.21 DID in 2011 to 13.16 DID in 2020. Consumption of beta-lactamase-sensitive penicillins, expressed as a percentage of the total consumption of antibiotics, decreased from 8.4% in 2011 to 4.2% in 2020. Consumption of the combination of penicillins, including beta-lactamase inhibitor, expressed as a percentage of the total consumption of antibiotics, increased from 16.2% in 2011 to 17.9% in 2020. Consumption of third- and fourth-generation cephalosporins, expressed as the percentage of the total consumption of antibiotics, increased from 2.0% in 2011 to 4.6% in 2020. Consumption of fluoroquinolones, expressed as the percentage of the total consumption of antibiotics, decreased from 10.7% in 2011 to 8.6% in 2020. Overall, antibiotic consumption significantly changed in Slovakia from 2011 to 2020. The ratio of the consumption of broad-spectrum to the consumption of narrow-spectrum penicillins, cephalosporins and macrolides decreased from 14.98 in 2011 to 13.38 in 2020. Full article
(This article belongs to the Special Issue Antibiotic Use in European Hospitals and Pharmacies)
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