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Antibiotics
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Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop...
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Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop and Evaluate Antimicrobial Stewardship Interventions

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 8717

Special Issue Editors

Prof. Dr. Gyöngyvér Soós

E-Mail Website
Guest Editor
Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, 6725 Szeged, Hungary
Interests: clinical pharmacy; medication use; antibiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Ria Benkő

E-Mail Website
Guest Editor
1. Clinical Pharmacy Department, Faculty of Pharmacy, University of Szeged, H-6725 Szeged, Hungary
2. Central Pharmacy, Albert Szent-Györgyi Medical Center, University of Szeged, H-6725 Szeged, Hungary
3. Emergency Department, Albert Szent-Györgyi Health Centre, University of Szeged, Semmelweis Street 6, H-6725 Szeged, Hungary
Interests: drug utilization research regarding antibiotics both ambulatory and hospital settings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial use is one of the main drivers of antimicrobial resistance (AMR), a crisis that threatens modern medicine. AMR can be reversed, and rationalizing antibiotic use is an effective tool to achieve this.

This Special Issue focuses on human antimicrobial exposure, but we also aim to include One Health-related research. We seek the submission of new findings from different countries, different healthcare settings, and different patient populations, including vulnerable patient populations (elderly, paediatric, etc). We aim to involve various study designs and levels of analysis (population-based studies, registry-based data, local patient level field studies, surveys). Both quantitative and qualitative research methods are welcomed in this Special Issue, focusing on drug utilisation data, determinants of antimicrobial use, safety issues, and the effect of interventions.

If you have any questions or are unsure whether your study fits within the scope of this Special Issue, please contact the Antibiotics Editorial Office.

Prof. Dr. Gyöngyvér Soós
Dr. Ria Benkő
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality of antibiotic use
  • scale of antibiotic use
  • pattern of antibiotic use
  • prevalence of antibiotic use
  • specific patient populations
  • safety of use
  • antibacterial
  • antivirals
  • antifungals
  • anti-TBC

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

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25 pages, 4648 KB  
Article
Impact of an Antimicrobial Stewardship Program on Antibiotic Consumption, Bacterial Susceptibility, and Costs in a High-Complexity Public Hospital
by Jéssica Cristina Bilizario Noguerol Andrade, Beatriz Souza Santos and Fernando de Sá Del Fiol
Antibiotics 2026, 15(3), 264; https://doi.org/10.3390/antibiotics15030264 - 3 Mar 2026
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Abstract
Background/Objectives: Antimicrobial resistance (AMR) is a major global public health threat, particularly in hospitals. Antimicrobial Stewardship Programs (ASPs) aim to optimize prescribing, reduce unnecessary exposure to broad-spectrum agents, and mitigate resistance. This study evaluated the clinical, ecological, and economic impact of an [...] Read more.
Background/Objectives: Antimicrobial resistance (AMR) is a major global public health threat, particularly in hospitals. Antimicrobial Stewardship Programs (ASPs) aim to optimize prescribing, reduce unnecessary exposure to broad-spectrum agents, and mitigate resistance. This study evaluated the clinical, ecological, and economic impact of an ASP implemented in January 2021 in a high-complexity hospital in Brazil, focusing on antimicrobial consumption, temporal trends in bacterial susceptibility, and direct antimicrobial-related costs. Methods: A quasi-experimental pre–post study using an interrupted time-series design was conducted in the adult intensive care unit from January 2019 to December 2023. Antimicrobial consumption was measured as Defined Daily Doses per 1000 patient-days (DDD/1000-PD) for ceftriaxone, meropenem, piperacillin–tazobactam, vancomycin, and polymyxin B. Temporal trends were assessed using Joinpoint regression, and pre- and post-intervention periods were compared using Student’s or Mann–Whitney tests. Susceptibility data were interpreted according to BrCAST standards. Results: Significant and sustained reductions were observed for all agents except polymyxin B. Susceptibility improved or stabilized among key Gram-negative pathogens, with a significant increase in aggregated Gram-negative susceptibility after 2021, while intrinsically resistant organisms showed limited change. Annual antimicrobial costs decreased by approximately USD 174,000. Conclusions: The ASP was associated with reduced broad-spectrum antimicrobial use, favorable ecological trends, and substantial cost savings. Full article
(This article belongs to the Special Issue Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop and Evaluate Antimicrobial Stewardship Interventions)
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24 pages, 845 KB  
Systematic Review
The Impact of Antibiotic Prophylaxis on Antibiotic Resistance, Clinical Outcomes, and Costs in Adult Hemato-Oncological and Surgical Patients: A Systematic Review and Meta-Analysis
by Marissa Rink, Beryl Primrose Gladstone, Lea Ann Nikolai, Michael Bitzer, Evelina Tacconelli and Siri Göpel
Antibiotics 2025, 14(9), 853; https://doi.org/10.3390/antibiotics14090853 - 22 Aug 2025
Cited by 4 | Viewed by 7036
Abstract
Background/Objectives: While antibiotic prophylaxis is crucial for preventing infections, its impact on the development of antibiotic-resistant infections and clinical outcomes remains underexplored. We aimed to systematically assess the impact of medical and surgical antibiotic prophylaxis (SAP) on the development of antibiotic-resistant infections, clinical [...] Read more.
Background/Objectives: While antibiotic prophylaxis is crucial for preventing infections, its impact on the development of antibiotic-resistant infections and clinical outcomes remains underexplored. We aimed to systematically assess the impact of medical and surgical antibiotic prophylaxis (SAP) on the development of antibiotic-resistant infections, clinical outcomes, and costs. Methods: A systematic review and meta-analysis of the effect of antibiotic prophylaxis on antibiotic-resistant infections, mortality, length of hospital stay, and/or costs was conducted in hemato-oncological or surgical patient populations. Pooled estimates of the relative risk (RR) or weighted mean difference (WMD) were derived using random-effect meta-analysis. Results: Of 10,409 screened studies, 109 (30%) comprising 131,519 patients were included. In 55 hemato-oncological studies, prophylaxis significantly reduced Gram-negative infections (RR: 0.51; 95% CI: 0.45 to 0.59) without an effect on mortality (RR = 1.01; 95% CI: 0.89 to 1.15), while the risk of developing an infection resistant to prophylactic antibiotics during hospitalization was doubled (RR: 2.05; 95% CI: 1.88 to 2.23). The length of hospitalization was reduced by 1.85 days. Among 54 surgical studies, SAP lowered surgical-site infections (RR: 0.58; 95% CI: 0.49 to 0.69). Extending prophylaxis beyond the recommended duration did not improve infection rates (RR: 1.10; 95% CI: 0.98 to 1.24). No association was demonstrated between prophylaxis adjusted by colonization status and the development of resistant infections. Conclusion: Though proven beneficial, our results highlight the critical need for targeted antibiotic stewardship programs (ASPs) in both settings. A meticulous risk assessment balancing the benefits of preventing life-threatening infections against the risk of driving antimicrobial resistance, and a tailored ASP, is urgently needed for hemato-oncological patients. Full article
(This article belongs to the Special Issue Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop and Evaluate Antimicrobial Stewardship Interventions)
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