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Antibiotics
Special Issues
Antimicrobial Activity of Extracts from Plants, 2nd Edition
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Antimicrobial Activity of Extracts from Plants, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 3747

Special Issue Editors

Dr. Lucia Recinella

E-Mail Website
Guest Editor
Department of Pharmacy, “G. d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy
Interests: pharmaco-toxicological evaluations of herbal extracts; neuroendocrine regulation; GHRH deficiency
Special Issues, Collections and Topics in MDPI journals
Dr. Sheila Leone

E-Mail Website1 Website2
Guest Editor
Department of Pharmacy, “G. d'Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy
Interests: pharmaco-toxicological evaluations of herbal extracts; neuroendocrine regulation; GHRH deficiency
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We published a successful Special Issue titled “Antimicrobial Activity of Extracts from Plants”. This encouraged us to open a second edition on the same topic, welcoming original research papers and comprehensive reviews.

Novel antimicrobial agents are required to reduce toxicity and emerging microbial resistance related to conventional chemotherapeutic and antifungal drugs. Medicinal plants contain numerous bioactive secondary metabolites, including flavonoids, coumarins, tannins, alkaloids, and terpenoids, which have antimicrobial, anti-inflammatory, and antioxidant effects. The goal of this Special Issue is to evaluate the effects of antimicrobial activities on specific bacterial strains and fungi involved in chronic inflammatory and infectious diseases. Investigations involving the characterization of phytochemical and botanical properties related to tested extracts, cytotoxicity determination, mechanisms of action, and pharmaco-toxicological evaluations are encouraged.

You are welcome to read the published papers in the first Special Issue titled “Antimicrobial Activity of Extracts from Plants”.

Acknowledgment: Maria Loreta LIbero will be participating in this special issue as a "Special collaborator", and special thanks for her contribution to the special issue.

Dr. Lucia Recinella
Dr. Sheila Leone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • metabolomic fingerprint
  • bioinformatics

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Related Special Issue

Published Papers (2 papers)

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Research

14 pages, 4780 KiB  
Article
Inhibitory Effect of Moringa oleifera Seed Extract and Its Behenic Acid Component on Staphylococcus aureus Biofilm Formation
by Seoyoung Kim and Tae-Jong Kim
Antibiotics 2025, 14(1), 19; https://doi.org/10.3390/antibiotics14010019 - 31 Dec 2024
Viewed by 1017
Abstract
Background/Objectives: Inhibiting biofilm formation without killing cells facilitates the physical removal of contaminating bacteria while minimizing the opportunity for resistant bacteria to emerge. Results: The M. oleifera methanolic seed extract contained 1.48% behenic acid, significantly inhibiting S. aureus biofilm formation. Although [...] Read more.
Background/Objectives: Inhibiting biofilm formation without killing cells facilitates the physical removal of contaminating bacteria while minimizing the opportunity for resistant bacteria to emerge. Results: The M. oleifera methanolic seed extract contained 1.48% behenic acid, significantly inhibiting S. aureus biofilm formation. Although behenic acid did not affect cell growth, it inhibited biofilm formation in a concentration-dependent manner, up to 20 mg/L. The cell physiology changes caused by behenic acid are potentially unrelated to biofilm formation inhibition, as no correlation was noted between cell hydrophobicity, polysaccharide production, extracellular DNA production, or protein production and behenic acid concentration. Thus, it was hypothesized that the surfactant properties of behenic acid contribute to its ability to inhibit biofilm formation, as a similar biofilm-inhibitory effect was observed when S. aureus was administered 1% Tween 80, a surfactant. Methods: A methanolic extract of Moringa oleifera seeds was selected from a library of edible plant extracts to inhibit Staphylococcus aureus biofilm formation without cell killing. Conclusions: Behenic acid is a saturated fatty acid that is used as an ingredient in cosmetics and ointments; thus, behenic acid may benefit the skin by inhibiting the biofilm formation of S. aureus, a commensal skin pathogen. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Extracts from Plants, 2nd Edition)
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14 pages, 3842 KiB  
Article
Beneficial Effects Induced by a Proprietary Blend of a New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine in Urinary Tract Infections: Results from In Vitro and Ex Vivo Studies
by Lucia Recinella, Morena Pinti, Maria Loreta Libero, Silvia Di Lodovico, Serena Veschi, Anna Piro, Daniele Generali, Alessandra Acquaviva, Nilofar Nilofar, Giustino Orlando, Annalisa Chiavaroli, Claudio Ferrante, Luigi Menghini, Simonetta Cristina Di Simone, Luigi Brunetti, Mara Di Giulio and Sheila Leone
Antibiotics 2024, 13(10), 985; https://doi.org/10.3390/antibiotics13100985 - 18 Oct 2024
Viewed by 2287
Abstract
Background/Objectives: Urinary tract infections (UTIs) are infections that involve the urethra, bladder, and, in much more severe cases, even kidneys. These infections represent one of the most common diseases worldwide. Various pathogens are responsible for this condition, the most common being Escherichia coli [...] Read more.
Background/Objectives: Urinary tract infections (UTIs) are infections that involve the urethra, bladder, and, in much more severe cases, even kidneys. These infections represent one of the most common diseases worldwide. Various pathogens are responsible for this condition, the most common being Escherichia coli (E. coli). Bromelain is a proteolytic complex obtained from the stem and stalk of Ananas comosus (L.) Merr. showing several beneficial activities. In addition to bromelain, N-acetylcysteine (NAC) has also been used. Methods: The purpose of this experiment was to evaluate the antibacterial, anti-motility, and anti-biofilm effects of a new polyenzymatic complex (DIF17BRO®) in combination with NAC (the Formulation) on various strains of E. coli isolated from patients with UTIs. Subsequently, the anti-inflammatory and antioxidant effects of the Formulation were studied in an ex vivo model of cystitis, using bladder samples from mice exposed to E. coli lipopolysaccharide (LPS). Results: Our results showed that the Formulation significantly affects the capability of bacteria to form biofilm and reduces the bacteria amount in the mature biofilm. Moreover, it combines the interesting properties of NAC and a polyenzyme plant complex based on bromelain in a right dose to affect the E. coli adhesion capability. Finally, the Formulation exhibited protective effects, as confirmed by the inhibitory activities on multiple inflammatory and oxidative stress-related pathways on bladder specimens exposed to LPS. Conclusions: This blend of active compounds could represent a promising and versatile approach to use to overcome the limitations associated with conventional therapies. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Extracts from Plants, 2nd Edition)
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