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Antibiotics
Special Issues
Antibiotics in Pathogen Control: From Infection to Antimicrobial Resistance
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Antibiotics in Pathogen Control: From Infection to Antimicrobial Resistance

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1706

Special Issue Editor

Dr. Alessia Catalano

E-Mail Website
Guest Editor
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70126 Bari, Italy
Interests: antibacterials; antifungals; antitumor agents; antiviral; medicinal chemistry; toxicology; small molecules; antimyotonic agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pathogens, intended in the oldest and broadest sense, are any organism or agent that can produce disease. These agents can invade tissues, multiply, and produce toxic substances that cause disease. The term “pathogen” may also be referred to simply as a “germ”. This Special Issue explores studies on all aspects of pathogen infections. The paper can include: medicinal-chemistry studies regarding infections caused by pathogens; sepsis; infections caused by emerging and/or pathogens; multidisciplinary (One-Health) approach; identification and characterization of pathogens; pathogen invasion and host defenses; pathogen–host interactions; Vector-borne diseases; transmission of pathogens; pathogen genetics and genomics; pathogen lifecycle; host adaptation; pathogen Inactivation; innate and adaptive immune responses; molecular mechanisms of host-pathogen interaction; zoonotic diseases; vaccine and therapeutic development; immune defense mechanisms; veterinary infections; cell signaling; drug–drug interactions; antimicrobial resistance; resistance to antiparasitic treatments for both public and veterinary health; experimental and computational studies; activity of natural products, including studies on compounds derived from plants, algae, microorganisms, animals, and marine organisms, employing in vivo, in vitro, and in silico methods; natural product chemistry; natural products chemistry and interdisciplinary approaches; and resistant pathogens (MDR, XDR, DTR, CR, and PDR bacteria and MBL-producing bacteria).

This Special Issue of Antibiotics aims to address contributions to this complex field. We invite submissions of reviews, regular research papers, and communications related to this topic.

We look forward to receiving your contributions. All submissions will undergo a rigorous peer review process to ensure scientific quality and relevance.

Dr. Alessia Catalano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • resistance
  • pathogens
  • antimicrobials
  • ESKAPEE
  • One-Health
  • natural products

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

14 pages, 16335 KB  
Article
Lemon Juice Activity Against Caprine Alphaherpesvirus-1: An In Vitro Study
by Francesco Pellegrini, Gianvito Lanave, Cristiana Catella, Vanessa Bachmann, Marinella Dibari, Maria Tempesta, Vito Martella, Nicola Decaro, Claudia Maria Trombetta and Michele Camero
Antibiotics 2026, 15(3), 295; https://doi.org/10.3390/antibiotics15030295 - 14 Mar 2026
Viewed by 658
Abstract
Caprine herpesvirus 1 (CpHV-1) is responsible for significant economic losses in goat farming. The CpHV-1 genital infection in goats has been used as a homologous animal model for the study of human herpes simplex virus type 2 (HSV-2). This study aimed to investigate [...] Read more.
Caprine herpesvirus 1 (CpHV-1) is responsible for significant economic losses in goat farming. The CpHV-1 genital infection in goats has been used as a homologous animal model for the study of human herpes simplex virus type 2 (HSV-2). This study aimed to investigate the in vitro virucidal and antiviral effect of lemon juice (LJ) and its main component, citric acid (CA), against CpHV-1 on Madin-Darby Bovine Kidney (MDBK) cells. Cytotoxicity was assessed using an XTT assay, while viral titers were determined by the Reed–Muench method and viral DNA was quantified via qPCR. Pure LJ (pH 2.3) and its corresponding CA solution demonstrated potent and rapid virucidal activity, reducing the viral titer by over 5.0 log10 TCID50/50 µL within 1 min. When applied after viral entry, a non-cytotoxic dilution of LJ (pH 4.32) significantly inhibited viral replication, causing a 2.5 log10 TCID50/50 µL reduction in viral titer and a corresponding decrease in viral DNA. The antiviral effects were minimal at a near-neutral pH of 6.67, probably interacting with envelope structures. These results suggest that LJ could be a potential low-cost topical agent or disinfectant for controlling CpHV-1 in goat populations and offer a basis for translational research on human herpesviruses. Full article
(This article belongs to the Special Issue Antibiotics in Pathogen Control: From Infection to Antimicrobial Resistance)
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10 pages, 571 KB  
Article
Screening and Cohorting of CRE Patients: The Strategic Role of Bed Management in a Monocentric Pre–Post Observational Study
by Salvatore Altavilla, Nicoletta Di Pietro, Daniela Loconsole and Francesco Di Gennaro
Antibiotics 2026, 15(3), 290; https://doi.org/10.3390/antibiotics15030290 - 12 Mar 2026
Viewed by 682
Abstract
Background: Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and isolation strategies; however, evidence on its impact on patient flow and isolation practices remains limited. Aim: [...] Read more.
Background: Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and isolation strategies; however, evidence on its impact on patient flow and isolation practices remains limited. Aim: To evaluate whether the implementation of a Bed Management-coordinated structured CRE screening pathway was associated with changes in patient placement appropriateness and time to admission (TTA). Methods: We conducted a retrospective cohort study including all patients with a positive rectal swab for CRE during two study periods (PRE: 2024; POST: 2025) in a tertiary care hospital. A structured CRE screening pathway coordinated by Bed Management was implemented in the POST period. Primary outcomes were cohort isolation rates and TTA. Continuous variables were compared using the Mann–Whitney U test and categorical variables using the chi-square test. Results: A total of 158 CRE-positive patients were included (69 in the PRE period and 89 in the POST period). Patient characteristics were comparable between periods (median age 75 years [IQR 64–81] vs. 73 years [IQR 64–82]; female sex 33.3% vs. 44.9%, p = 0.189). Cohort isolation rates were higher in the POST period. Median time to admission (TTA) decreased from 74.8 h (IQR 47.2–124.6) in PRE to 70.7 h (IQR 35.1–139.9) in POST; however, this difference did not reach statistical significance (Mann–Whitney U test, p = 0.630). Conclusions: A Bed Management-coordinated CRE screening pathway was associated with improved cohort isolation practices and an observed, non-significant reduction in TTA. These findings suggest that integrating infection prevention workflows with centralized bed allocation may be feasible without adversely affecting admission timeliness. Further studies with larger samples and longer observation periods are warranted. Full article
(This article belongs to the Special Issue Antibiotics in Pathogen Control: From Infection to Antimicrobial Resistance)
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