Antiprotozoal Activity of Natural Products: 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1203

Special Issue Editors


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Guest Editor
Chemistry Interdisciplinary Project (CHIP), School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
Interests: medicinal chemistry; small-molecules; essential oils; naturally-occurring compounds; NAD-dependent enzymes; plant secondary metabolites; bioactive-active fractionation; phytochemicals; ethnopharmacology; biological activity of natural compounds
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Special Issue Information

Dear Colleagues,

The success of the first volume of this Special Issue, entitled "Antiprotozoal Activity of Natural Products" (https://www.mdpi.com/journal/antibiotics/special_issues/anti_protozoal_activity), encourages us to open a second volume focused on the same topic.

As a continuation of the first Special Issue, the second volume will gather review papers and original articles dealing with the potential antiprotozoal activities of plant secondary metabolites, including different classes such as terpenoids, alkaloids, and phenolics. This Special Issue welcomes contributions on the following topics:

  • Phytochemical analysis and biological evaluation (in vitro and/or in vivo studies) of plant extracts/essential oils and isolated compounds.
  • Mode of action (MoA) studies of natural products.
  • Structure–activity relationship (SAR) studies, including hemi-synthesized molecules.
  • Synergistic and antagonistic studies of mixtures of natural products.
  • Development of new antiprotozoal agent formulations.

Prof. Dr. Filippo Maggi
Dr. Riccardo Petrelli
Guest Editors

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Keywords

  • botanicals
  • secondary metabolites
  • isolation
  • structural elucidation
  • anti-protozoal activity

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Published Papers (1 paper)

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Research

12 pages, 1492 KiB  
Article
Antiparasitic Activity of Isolated Fractions from Parthenium incanum Kunth against the Hemoflagellate Protozoan Trypanosoma cruzi
by David Alejandro Hernández-Marín, Rocio Castro-Rios, Abelardo Chávez-Montes, Sandra L. Castillo-Hernández, Joel Horacio Elizondo-Luevano, Martín Humberto Muñoz-Ortega and Eduardo Sánchez-García
Antibiotics 2024, 13(7), 622; https://doi.org/10.3390/antibiotics13070622 - 4 Jul 2024
Cited by 1 | Viewed by 809
Abstract
This study focused on isolating, identifying, and evaluating the trypanocidal potential against the hemoflagellate protozoan Trypanosoma cruzi of compounds from Parthenium incanum (Mariola), a plant used in traditional Mexican medicine to treat stomach and liver disorders. P. incanum has a wide distribution in [...] Read more.
This study focused on isolating, identifying, and evaluating the trypanocidal potential against the hemoflagellate protozoan Trypanosoma cruzi of compounds from Parthenium incanum (Mariola), a plant used in traditional Mexican medicine to treat stomach and liver disorders. P. incanum has a wide distribution in Mexico. This study found that methanolic extracts of P. incanum, obtained by static maceration and successive reflux, had promising results. The fractions were compared using thin-layer chromatography (TLC) and those that showed similarities were mixed. A bioguided assay was performed with Staphylococcus aureus ATCC 25923, using agar diffusion and bioautography techniques to determine the preliminary biological activity. The fractions with antimicrobial activity were purified using a preparative thin-layer chromatography (PTLC) plate, obtaining the bioactive bandages that were subjected to a trypanocidal evaluation against the Ninoa strain of T. cruzi in its epimastigote stage. This revealed an IC50 of up to 45 ± 2.5 µg/mL, in contrast to the values obtained from the crude extracts of less than 100 µg/mL. The TLC, Fourier-transform infrared spectroscopy (FT-IR), and high-performance liquid chromatography coupled with mass spectrometry (HPLC–MS) techniques were used to identify the compounds, demonstrating the presence of sesquiterpene lactones, parthenin, and coronopolin. We concluded that these compounds have the potential to inhibit T. cruzi growth. Full article
(This article belongs to the Special Issue Antiprotozoal Activity of Natural Products: 2nd Edition)
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