Insights into Bacterial Resistance to Beta-Lactam Antibiotics and Treatment Approaches

Dear Colleagues,

Antimicrobial resistance (AMR), particularly to β-lactam antibiotics, is one of the most severe and complicated health issues globally, fueled by interconnected factors across human, animal, and environmental health sectors. The emergence and spread of multidrug-resistant bacterial strains worldwide have significantly reduced the efficacy of β-lactams, which have long been the cornerstone of antibacterial treatment. Understanding the molecular mechanisms driving β-lactam resistance, as well as developing innovative therapeutic and diagnostic strategies, is essential to preserving the effectiveness of these crucial drugs.

This Special Issue is dedicated to presenting recent advances and insights into bacterial resistance to β-lactam antibiotics, including novel β-lactamase enzymes, resistance gene dissemination, and the clinical impact of resistance on treatment outcomes.

We invite submissions of original research, comprehensive reviews, and case studies addressing innovative antimicrobial combinations, β-lactamase inhibitors, resistance detection methods, and emerging therapeutic strategies. Topics include the discovery of novel β-lactamase enzymes, the spread of resistance genes, and the clinical repercussions of resistance on treatment outcomes.

By integrating multidisciplinary perspectives, this issue seeks to contribute to the global effort against β-lactam resistance and guide future strategies in infection management.

Prof. Dr. Maria Chatzidimitriou
Dr. Efthymia Protonotariou
Guest Editors

Manuscript Submission Information

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