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Antibiotics
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Antibiotic Treatment and Antibiotic Resistance of Enterococcus Infections, 2nd Edition
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Antibiotic Treatment and Antibiotic Resistance of Enterococcus Infections, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1542

Special Issue Editors

Dr. Giovanni Boccia

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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”/DIPMED, University of Salerno, Baronissi, 84081 Salerno, Italy
Interests: hygiene; prophylaxis; healthcare-associated infections; microbiology; clinical pathology; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals
Dr. Gianluigi Franci

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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”/DIPMED, University of Salerno, Baronissi, 84081 Salerno, Italy
Interests: microbiology and virology; antimicrobial stewardship; medicine; epigenetic; drug discovery; alert germs
Special Issues, Collections and Topics in MDPI journals
Dr. Biagio Santella

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Guest Editor
Department of Experimental Medicine, Section of University of Campania "Luigi Vanvitelli", 80138 Naples, Italy
Interests: antibiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first volume of the Special Issue “Antibiotic Treatment and Antibiotic Resistance of Enterococcus Infections” was published in 2022. Following its success, we are pleased to announce the launch of a second volume, focusing on the same topic.

As a continuation of the Special Issue published in 2022, this second volume will also deliver an invaluable compendium of the latest treatments for Enterococcus infections and the latest research on antibiotic resistance in Enterococcus. Topics of interest may include, but are not limited to, the following:

  1. Epidemiological studies of enterococcal infection and trends in antibiotic resistance;
  2.  Discoveries and genetic studies of new drug resistance genes in Enterococci;
  3.  Surveillance of enterococcal resistance in healthcare settings;
  4. Antibiotic treatment of Enterococcus infections.

Dr. Giovanni Boccia
Dr. Gianluigi Franci
Dr. Biagio Santella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • antimicrobial resistance
  • enterococcus faecium
  • enterococcus faecalis
  • drug resistance
  • epidemiologic studies
  • endocarditis

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Related Special Issue

Published Papers (2 papers)

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16 pages, 1789 KB  
Article
Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium Isolates with Full and Truncated vanA Operons from Russian Hospitals
by Anna Slavokhotova, Andrey Shelenkov, Yulia Mikhaylova, Lyudmila Petrova, Vitaly Gusarov, Mikhail Zamyatin and Vasiliy Akimkin
Antibiotics 2025, 14(9), 858; https://doi.org/10.3390/antibiotics14090858 - 25 Aug 2025
Abstract
Background: Vancomycin-resistant Enterococcus faecium (VREfm), particularly vanA-positive strains, represents a growing threat in hospital settings worldwide. These bacteria are able to survive under severe environmental conditions, including high temperatures and saline concentrations. High genome plasticity and advanced ability of inheriting antimicrobial [...] Read more.
Background: Vancomycin-resistant Enterococcus faecium (VREfm), particularly vanA-positive strains, represents a growing threat in hospital settings worldwide. These bacteria are able to survive under severe environmental conditions, including high temperatures and saline concentrations. High genome plasticity and advanced ability of inheriting antimicrobial resistance determinants defined the success of E. faecium as a hospital pathogen. Methods: This study presents the whole genomic characterization of vanA-positive VREfm isolates, analyzing 10 clinical isolates collected from three tertiary care hospitals in Moscow, Russia. Several typing approaches, including two MLST schemes and cgMLST profiles, were used to elucidate the relationship between the isolates. Phylogenetic analysis placed the isolates in context with global VREfm populations, demonstrating both local clonal expansion and possible international connections. Phenotypic and genomic antimicrobial resistance profiles were obtained, as well as data regarding the repertoire of virulence factors and plasmid content. Results: Whole genome sequencing revealed that all isolates belonged to the clinically significant CC17 lineage, specifically sequence types ST80 and ST552. Notably, two isolates possessed truncated Tn1546-type transposons lacking vanY and vanZ genes, representing a potentially emerging variant of the vanA operon in Russian clinical settings. A plasmid carrying a truncated vanA operon was reconstructed using long-read sequencing. Conclusions: The study highlights the utility of genomic investigation for tracking resistance mechanisms and strain dissemination, providing crucial baseline data for epidemiological surveillance of infections caused by VREfm in Russia. These findings emphasize the need for continued genomic monitoring to understand the evolution and spread of antimicrobial resistance in clinically important enterococcal lineages. Full article
(This article belongs to the Special Issue Antibiotic Treatment and Antibiotic Resistance of Enterococcus Infections, 2nd Edition)
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10 pages, 3453 KB  
Case Report
Isolated Pulmonary Valve Endocarditis Caused by Enterococcus faecalis—Facing the Unpredictable
by Andrei Vâţă, Isabela Ioana Loghin, Radu Ștefan Miftode, Daniela Crişu, Cătălina Mihaela Luca, Alin Mihai Vasilescu, Ioana Maria Onofrei, Tudorița Parângă and Ionela-Larisa Miftode
Antibiotics 2025, 14(3), 220; https://doi.org/10.3390/antibiotics14030220 - 21 Feb 2025
Cited by 1 | Viewed by 1051
Abstract
Background: Infective endocarditis is a severe, life-threatening condition which affects the endocardial lining of the heart. Right-sided IE typically affects the tricuspid valve and, less commonly, the pulmonary valve, often in association with intravenous drug use and intracardiac devices. Enterococcus faecalis, a [...] Read more.
Background: Infective endocarditis is a severe, life-threatening condition which affects the endocardial lining of the heart. Right-sided IE typically affects the tricuspid valve and, less commonly, the pulmonary valve, often in association with intravenous drug use and intracardiac devices. Enterococcus faecalis, a significant pathogen in healthcare settings, is frequently resistant to several antibiotics, complicating treatment. Results: We present the case of a 69-year-old man diagnosed with isolated pulmonary valve endocarditis, with no identifiable risk factors, good oral hygiene, and no recent dental procedures. In our case, the E. faecalis strain, initially susceptible to ampicillin, acquired resistance during high-dose ampicillin and gentamicin therapy, leading to cardiac surgery and prolonged antibiotic treatment. Conclusions: IPE is rare, emphasizing the need for heightened clinical awareness and thorough diagnostic evaluation, especially in patients with endocarditis symptoms and known risk factors. Although ampicillin resistance in E. faecalis is uncommon, its emergence during treatment presents a challenge, necessitating careful antibiotic stewardship to improve outcomes. Full article
(This article belongs to the Special Issue Antibiotic Treatment and Antibiotic Resistance of Enterococcus Infections, 2nd Edition)
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