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Antibiotics
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Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New...
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Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 15725

Special Issue Editors

Dr. Paola Angelini

E-Mail Website1 Website2
Guest Editor
Department of Chemistry, Biology, and Biotechnology, University of Perugia, 06122 Perugia, Italy
Interests: biodiversity; biological activities; dermatophyte; essential oils; medicinal Plants; mushrooms; non-volatile extracts
Special Issues, Collections and Topics in MDPI journals
Dr. Carolina Girometta

E-Mail Website
Guest Editor
Department of Earth and Environmental Sciences, University of Pavia, Via Sant’Epifanio 14, 27100 Pavia, Italy
Interests: mycology; plant pathology; systematics; taxonomy; ecology; bioremediation; mushroom cultivation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi produce a wide range of natural products, often called secondary metabolites (low-molecular weight compounds), e.g., polyketides, non-ribosomal peptides, and terpenes. Interest in these compounds is considerable, as many natural products are of medical, industrial, and/or agricultural importance. 

In this Special Issue dedicated to “Natural Bioactive Compounds from Fungi with Potential Medicinal Properties: New and Future Developments in Microbial Biotechnology”, research papers and reviews on the search for new fungal metabolites for the pharmaceutical and agrochemical industries are welcome, providing new evidence about fungi as potential sources of bioactive or more largely useful properties.

Due to the increasing resistance of microorganisms to synthetic antibiotics, research on new antibacterial and new antifungal agents, as well as investigations of the biosynthetic pathways of already known or new molecules, at a laboratory scale or at a pilot level, could be emphasized.

Additional biotechnological processes for industrial applications and/or alternative use of fungal compounds in food, beverage, supplements, cosmetic, bio-based materials, or painting industries could also be part of this Special Issue.

Dr. Paola Angelini
Dr. Carolina Girometta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobials
  • biological properties
  • biosynthesis
  • endophytic fungi
  • filamentous fungi
  • food, beverages, and supplements
  • fungal biotechnology
  • industrial application
  • secondary metabolites
  • screening

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Published Papers (5 papers)

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Research

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15 pages, 2264 KiB  
Article
Fomitopsis officinalis: Spatial (Pileus and Hymenophore) Metabolomic Variations Affect Functional Components and Biological Activities
by Giancarlo Angeles Flores, Gaia Cusumano, Federica Ianni, Francesca Blasi, Paola Angelini, Lina Cossignani, Roberto Maria Pellegrino, Carla Emiliani, Roberto Venanzoni, Gokhan Zengin, Alessandra Acquaviva, Simonetta Cristina Di Simone, Maria Loreta Libero, Nilofar, Giustino Orlando, Luigi Menghini and Claudio Ferrante
Antibiotics 2023, 12(4), 766; https://doi.org/10.3390/antibiotics12040766 - 16 Apr 2023
Cited by 6 | Viewed by 2392
Abstract
Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F. officinalis is a medicinal mushroom species that is most commonly used in traditional European medicine. In this study, we explore the spatial [...] Read more.
Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F. officinalis is a medicinal mushroom species that is most commonly used in traditional European medicine. In this study, we explore the spatial metabolic differences in F. officinalis’ mushroom parts, i.e., the cap (median and apical parts) and the hymenium. Additionally, chromatographic analysis was conducted in order to unravel the composition of specialized metabolites in the hydroalcoholic mushroom extracts. The potential antifungal and bacterial effects of extracts were tested against pathogen strains of Gram+ and Gram– bacteria, and yeast, dermatophytic, and fungal-pool species. Extracts from the apical part were the richest in terms of phenolic compounds; consistent with this finding, the extracts were also the most effective antiradical and antimicrobial agents with MIC values < 100 µg/mL for most of the tested bacterial and dermatophytic species. According to these findings, F. officinalis extracts are valuable sources of primary and secondary metabolites, thus suggesting potential applications in the formulation of food supplements with biological properties in terms of antioxidant and antimicrobial activities. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology)
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12 pages, 2554 KiB  
Article
Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
by Jing Wu, Takeru Ohura, Ryuhei Ogura, Junhong Wang, Jae-Hoon Choi, Hajime Kobori, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Esteban C. Gabazza, Yuichi Takikawa, Hirofumi Hirai and Hirokazu Kawagishi
Antibiotics 2023, 12(3), 596; https://doi.org/10.3390/antibiotics12030596 - 16 Mar 2023
Cited by 2 | Viewed by 2890
Abstract
A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar [...] Read more.
A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology)
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22 pages, 2003 KiB  
Article
Bioactive Components and Health Potential of Endophytic Micro-Fungal Diversity in Medicinal Plants
by Sundaram Muthukrishnan, Paranivasakam Prakathi, Thangavel Sivakumar, Muthu Thiruvengadam, Bindhu Jayaprakash, Venkidasamy Baskar, Maksim Rebezov, Marina Derkho, Gokhan Zengin and Mohammad Ali Shariati
Antibiotics 2022, 11(11), 1533; https://doi.org/10.3390/antibiotics11111533 - 2 Nov 2022
Cited by 11 | Viewed by 2967
Abstract
The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic fungi Graminicolous helminthosporium, Bipolaris australiensis and Cladosporium cladosporioides were isolated from different medicinal plants. The GC-MS analysis of intra- and extracellular products of [...] Read more.
The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic fungi Graminicolous helminthosporium, Bipolaris australiensis and Cladosporium cladosporioides were isolated from different medicinal plants. The GC-MS analysis of intra- and extracellular products of endophytic fungi revealed the presence of various bioactive metabolites, such as Anthracene, Brallobarbital, Benzo [h] quinolone, Ethylacridine, 2-Ethylacridine, Cyclotrisiloxane, 5 methyl 2 phenylindolizine, and 1,4-Cyclohexadien-1-one, etc. The phytochemical composition analysis of endophytic fungus extracts also revealed the presence of flavonoids, phenols, saponins, carbohydrates, glycosides, and proteins. The intra- and extracellular endophytic extracts exhibited strong antibacterial and antioxidant activity, which was screened with the agar-well diffusion method and DPPH, H2O2, and nitric oxide scavenging activity, respectively. The bioactive compounds identified in the endophytic extracts from GC-MS profiling served as ligands for molecular-docking analysis to investigate the anticancer potential against non-small cell lung carcinoma receptor EGFR. Molecular docking results showed that compounds, such as Brallobarbital, and 5 methyl 2 phenylindolizine had the lowest E- min values, which suggests that these compounds could be used in anticancer drug development. Thus, the isolated endophytic fungal species can be used to produce various bioactive compounds that could be used in novel drug development from natural sources and reduce the environmental burden of synthetic chemical drugs. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology)
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21 pages, 2114 KiB  
Article
Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from Pleurotus spp. Mycelium Grown in Different Culture Media
by Giancarlo Angeles Flores, Carolina Elena Girometta, Gaia Cusumano, Paola Angelini, Bruno Tirillini, Federica Ianni, Francesca Blasi, Lina Cossignani, Roberto Maria Pellegrino, Carla Emiliani, Roberto Venanzoni, Giuseppe Venturella, Pasqualina Colasuonno, Fortunato Cirlincione, Maria Letizia Gargano, Gokhan Zengin, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Luigi Menghini and Claudio Ferranteadd Show full author list remove Hide full author list
Antibiotics 2022, 11(11), 1468; https://doi.org/10.3390/antibiotics11111468 - 25 Oct 2022
Cited by 9 | Viewed by 2521
Abstract
Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles [...] Read more.
Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles of Pleurotus spp. mycelia grown in two substrates: Potato-dextrose-agar-PDA, used as control (S1), and PDA enriched with 0.5 % of wheat straw (S2). The main finding was that the metabolic pathways are strongly influenced by the chemical composition of the growth substrate. The antibacterial effects were particularly evident against Escherichia coli, whereas Arthroderma curreyi (CCF 5207) and Trichophyton rubrum (CCF 4933) were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on Pleurotus spp. antimicrobial and antioxidant properties. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology)
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Review

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31 pages, 3885 KiB  
Review
Coumarins as Fungal Metabolites with Potential Medicinal Properties
by Olga M. Tsivileva, Oleg V. Koftin and Nina V. Evseeva
Antibiotics 2022, 11(9), 1156; https://doi.org/10.3390/antibiotics11091156 - 26 Aug 2022
Cited by 43 | Viewed by 3994
Abstract
Coumarins are a structurally varied set of 2H-chromen-2-one compounds categorized also as members of the benzopyrone group of secondary metabolites. Coumarin derivatives attract interest owing to their wide practical application and the unique reactivity of fused benzene and pyrone ring systems [...] Read more.
Coumarins are a structurally varied set of 2H-chromen-2-one compounds categorized also as members of the benzopyrone group of secondary metabolites. Coumarin derivatives attract interest owing to their wide practical application and the unique reactivity of fused benzene and pyrone ring systems in molecular structure. Coumarins have their own specific fingerprints as antiviral, antimicrobial, antioxidant, anti-inflammatory, antiadipogenic, cytotoxic, apoptosis, antitumor, antitubercular, and cytotoxicity agents. Natural products have played an essential role in filling the pharmaceutical pipeline for thousands of years. Biological effects of natural coumarins have laid the basis of low-toxic and highly effective drugs. Presently, more than 1300 coumarins have been identified in plants, bacteria, and fungi. Fungi as cultivated microbes have provided many of the nature-inspired syntheses of chemically diverse drugs. Endophytic fungi bioactivities attract interest, with applications in fields as diverse as cancer and neuronal injury or degeneration, microbial and parasitic infections, and others. Fungal mycelia produce several classes of bioactive molecules, including a wide group of coumarins. Of promise are further studies of conditions and products of the natural and synthetic coumarins’ biotransformation by the fungal cultures, aimed at solving the urgent problem of searching for materials for biomedical engineering. The present review evaluates the fungal coumarins, their structure-related peculiarities, and their future therapeutic potential. Special emphasis has been placed on the coumarins successfully bioprospected from fungi, whereas an industry demand for the same coumarins earlier found in plants has faced hurdles. Considerable attention has also been paid to some aspects of the molecular mechanisms underlying the coumarins’ biological activity. The compounds are selected and grouped according to their cytotoxic, anticancer, antibacterial, antifungal, and miscellaneous effects. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds from Fungi with Potential Antimicrobial Properties: New and Future Developments in Microbial Biotechnology)
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