Special Issue "Veterinary Clinical Studies on Dairy Cattle and Dogs"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Dr. Raffaella Cocco
Guest Editor
Università degli Studi di Sassari, Sassari, Italy
Interests: animal welfare; oxidative stress; internal medicine; behavioral pathology; adverse reactions to food; circus animals; effects of the human-animal relationship

Special Issue Information

Dear Colleagues,

We are proposing a Special Issue based on Veterinary Clinical Studies on Dairy Cattle and Dogs. The transition period in dairy cattle includes significant physiological changes, which increase the risk of metabolic imbalances. The multitude of ailments that dairy cows face during this period is a constant source of concern for milk producers, nutritionists, and veterinarians. The total incidence of disease during the many weeks after delivery constitutes a substantial part of all morbidity in dairy cows, with particularly high rates of dairy fever, the downer cow syndrome, hypomagnesaemia, ketosis, fatty liver, metritis, poor fertility, breast edema, mastitis, and displacement of abomas, among other problems. These disorders are often interdependent, and this, along with dramatic changes in endocrine function and the metabolism associated with childbirth and the initiation of breastfeeding, cause a difficult period that has been at the center of a great deal of research in recent decades. Veterinarians who deal with dog clinics are increasingly faced with pathologies related to strong selective pressure in dog breeding, with subjects increasingly predisposed to presenting metabolic pathologies, allergies, tumors, adverse reactions to food, and behavioral pathologies. How connected are these elements? How much do oxidative stress, selection, diet, and lifestyle influence the increase of these pathological conditions? What is the relationship between these factors, the intestinal microbiota, and behavior? There are many questions to which we would like to find answers in this Special Issue.

Dr. Raffaella Cocco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Ketosis in dairy cattle
  • Hypocalcemia
  • Selection and pathology
  • Gut microbiota in dogs
  • Oxidative stress
  • Adverse food reactions in dogs

Published Papers (1 paper)

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Open AccessArticle
Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE)
Animals 2021, 11(4), 1044; https://doi.org/10.3390/ani11041044 - 08 Apr 2021
Viewed by 231
Discoid lupus erythematous (DLE) is a common autoimmune skin disorder of dogs where keratinocytes play a pivotal role both in the innate and adaptive immune responses. As for the innate response, pattern recognition receptors (PRR), including Toll-like receptors (TLRs), can activate macrophages and [...] Read more.
Discoid lupus erythematous (DLE) is a common autoimmune skin disorder of dogs where keratinocytes play a pivotal role both in the innate and adaptive immune responses. As for the innate response, pattern recognition receptors (PRR), including Toll-like receptors (TLRs), can activate macrophages and immune tissue cells allowing for transmission and transduction of signals through cytokine and chemokine release to improve host defenses. In particular, TLR4 can also recognize endogenous molecules such as heat shock proteins produced during reactions to tissue damage. The aim of this study was to evaluate the expression of TLR4, a bacterial lipopolysaccharide sensor, in the skin of dogs with DLE and in normal skin to evaluate a possible involvement of this receptor in the disease pathogenesis. Skin samples of affected dogs had a diffuse and intense expression of TLR4 in the epidermis. Also, the inflammatory infiltrates were immunolabelled. The expression was significantly higher in DLE skin compared to normal skin (**** p < 0.0001). In conclusion, dogs with DLE showed an altered expression of TLR4, which might play an important pathogenic role in the ongoing immunopathologic process, thus being considered a valuable therapeutic potential target for DLE. Full article
(This article belongs to the Special Issue Veterinary Clinical Studies on Dairy Cattle and Dogs)
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