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Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE)

School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, Italy
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Academic Editor: Simon L. Priestnall
Animals 2021, 11(4), 1044; https://doi.org/10.3390/ani11041044
Received: 24 February 2021 / Revised: 6 April 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Veterinary Clinical Studies on Dairy Cattle and Dogs)
Discoid lupus erythematous (DLE) is a common autoimmune skin disorder of dogs. The aim of this study was to evaluate the expression of TLR4, a bacterial lipopolysaccharide sensor, in skin of dogs with DLE and in normal skin to evaluate a possible involvement of this receptor in the disease pathogenesis. Skin samples of affected dogs had a diffuse and intense expression of TLR4, both in the epidermis and in inflammatory infiltrates. The expression was higher in DLE skin compared to normal skin. The high TLR4 expression might play an important pathogenic role in the ongoing immunopathologic process.
Discoid lupus erythematous (DLE) is a common autoimmune skin disorder of dogs where keratinocytes play a pivotal role both in the innate and adaptive immune responses. As for the innate response, pattern recognition receptors (PRR), including Toll-like receptors (TLRs), can activate macrophages and immune tissue cells allowing for transmission and transduction of signals through cytokine and chemokine release to improve host defenses. In particular, TLR4 can also recognize endogenous molecules such as heat shock proteins produced during reactions to tissue damage. The aim of this study was to evaluate the expression of TLR4, a bacterial lipopolysaccharide sensor, in the skin of dogs with DLE and in normal skin to evaluate a possible involvement of this receptor in the disease pathogenesis. Skin samples of affected dogs had a diffuse and intense expression of TLR4 in the epidermis. Also, the inflammatory infiltrates were immunolabelled. The expression was significantly higher in DLE skin compared to normal skin (**** p < 0.0001). In conclusion, dogs with DLE showed an altered expression of TLR4, which might play an important pathogenic role in the ongoing immunopathologic process, thus being considered a valuable therapeutic potential target for DLE. View Full-Text
Keywords: dog; DLE; TLR4; skin; Toll-like receptors dog; DLE; TLR4; skin; Toll-like receptors
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MDPI and ACS Style

Di Cerbo, A.; Giusti, S.; Mariotti, F.; Spaterna, A.; Rossi, G.; Magi, G.E. Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE). Animals 2021, 11, 1044. https://doi.org/10.3390/ani11041044

AMA Style

Di Cerbo A, Giusti S, Mariotti F, Spaterna A, Rossi G, Magi GE. Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE). Animals. 2021; 11(4):1044. https://doi.org/10.3390/ani11041044

Chicago/Turabian Style

Di Cerbo, Alessandro; Giusti, Sara; Mariotti, Francesca; Spaterna, Andrea; Rossi, Giacomo; Magi, Gian E. 2021. "Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE)" Animals 11, no. 4: 1044. https://doi.org/10.3390/ani11041044

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