Dear Colleagues,

The research on oxidative stress in companion, production, and exotic animals has been growing rapidly in recent years. These studies have led to the knowledge that oxidant production and the antioxidant compensatory response occur differently according to animals’ physiological or pathological situation. In addition, biomarkers of oxidative stress have been used to monitor the disease progression or treatment of various diseases in different species, such as leishmaniosis or parvoviral enteritis in dogs and pneumonia or sepsis in pigs.

There are numerous assays that can be used to evaluate oxidative status. These assays can assess the antioxidant response by quantification of selected molecules (e.g., α-tocopherol, β-carotene, or glutathione) but also by the overall antioxidant status determination of a sample through the use of different assays such as Trolox equivalent antioxidant capacity (TEAC), the ferric reducing ability of plasma (FRAP), or cupric reducing antioxidant capacity (CUPRAC). In addition, the oxidants produced can be estimated individually (e.g., superoxide radical, carbonyls, F2-isoprostanes, and 8-hydroxyguanine) or through the overall oxidant status by using assays such as total oxidant status (TOS), ferric-xylenol orange (FOX), and reactive oxygen metabolite-derived compounds (d-ROMs).

With the increased research in this field, it has been shown that in addition to blood, these markers can also be measured in other sample types such as urine, milk, or saliva, opening new possibilities for use and application.

This Special Issue has the aim of advancing the research of biomarkers of oxidative stress in animals. Studies dealing with physiological or clinical applications of these biomarkers in different species and types of samples will be welcome as well as investigations about the analytical validation or development of new assays. They will undoubtedly contribute to a better knowledge of the possible use and applications of the assays for the evaluation of oxidative status in veterinary science.

Dr. Camila P Rubio
Guest Editor

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• analytical methods
• antioxidants
• clinical application
• comparative studies
• global assays
• reactive oxygen species