Saliva and Serum Markers in Animals Health Monitoring

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (3 March 2023) | Viewed by 4127

Special Issue Editors


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Guest Editor
Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain
Interests: biomarkers of health; behavioural experiment; salivary biomarkers; stress; animal welfare; behaviour; horse
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain
2. Department of Animal Production, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia, Campus de Espinardo S/N, Espinardo, 30100 Murcia, Spain
Interests: behavioural experiment; behavioural analysis; stress; saliva; animal welfare; pigs
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain
Interests: behavioural experiment; oxytocin; stress; saliva; hair; animal welfare; pigs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few decades, the development of assays and techniques for identifying and quantifying biomarkers of health and disease in animals has been immense. In particular, saliva has recently awakened scientific interest as a biological fluid for determining animal health status, since saliva is a minimally invasive sample that does not produce pain, and repeated samples can be obtained anytime and without specialised staff. Therefore, saliva is a very interesting fluid for monitoring not only the process of diseases but also stressful or positive situations. However, there is recent scientific evidence of different patterns of change in some biomarkers if assessed in saliva or serum, indicating a differentiated composition of both fluids in response to some diseases or potential interactions with an organism, mainly due to a local production of some analytes in the salivary glands. Thus, measuring the saliva and serum biomarkers can provide invaluable complementary information.

The present Special Issue brings the opportunity of collecting high-quality recent research, literature reviews or case reports regarding how biomarkers from either saliva or serum can be employed for monitoring disease conditions, stressful situations, reproductive status, physical efforts, positive situations, or any interaction which could compromise the health status in animals, not only in veterinarian species (dog, cat, horse or livestock) but also in any animal species (zoological or wildlife species).

Dr. María Dolores Contreras-Aguilar
Dr. Damián Escribano
Dr. Marina López-Arjona
Guest Editors

Manuscript Submission Information

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Keywords

  • biomarkers
  • saliva
  • serum
  • health status

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Published Papers (2 papers)

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Research

10 pages, 1304 KiB  
Article
Changes in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndrome
by Alberto Muñoz-Prieto, María Dolores Contreras-Aguilar, José Joaquín Cerón, Ignacio Ayala de la Peña, María Martín-Cuervo, Peter David Eckersall, Ida-Marie Holm Henriksen, Fernando Tecles and Sanni Hansen
Animals 2023, 13(8), 1367; https://doi.org/10.3390/ani13081367 - 16 Apr 2023
Cited by 4 | Viewed by 1745
Abstract
Equine gastric ulcer syndrome (EGUS) is a highly prevalent disease that affects horses worldwide. Within EGUS, two different forms have been described: equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD). The associated clinical signs cause detrimental activity performance, reducing the [...] Read more.
Equine gastric ulcer syndrome (EGUS) is a highly prevalent disease that affects horses worldwide. Within EGUS, two different forms have been described: equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD). The associated clinical signs cause detrimental activity performance, reducing the quality of life of animals. Saliva can contain biomarkers for EGUS that could be potentially used as a complementary tool for diagnosis. The objective of this work was to evaluate the measurements of calprotectin (CALP) and aldolase in the saliva of horses as potential biomarkers of EGUS. For this purpose, automated assays for the quantification of these two proteins were analytically validated and applied for detecting EGUS in a total of 131 horses divided into 5 groups: healthy horses, ESGD, EGGD, combined ESGD and EGGD, and horses with other intestinal pathologies. The assays showed good precision and accuracy in analytical validation, and they were able to discriminate between horses with EGUS and healthy horses, especially in the case of CALP, although they did not show significant differences between horses with EGUS and horses with other diseases. In conclusion, salivary CALP and aldolase can be determined in the saliva of horses and further studies are warranted to elucidate the potential of these analytes as biomarkers in EGUS. Full article
(This article belongs to the Special Issue Saliva and Serum Markers in Animals Health Monitoring)
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10 pages, 1620 KiB  
Article
Comparative Analysis of Saliva and Plasma Proteins Patterns in Pregnant Cows—Preliminary Studies
by Wioleta Mojsym, Jacek Wawrzykowski, Monika Jamioł, Łukasz Chrobak and Marta Kankofer
Animals 2022, 12(20), 2850; https://doi.org/10.3390/ani12202850 - 20 Oct 2022
Cited by 3 | Viewed by 1835
Abstract
Pregnancy is a physiological state that can be described, from a biochemical point of view, using protein patterns. The present study focused on the comparison of protein patterns between the saliva and plasma of pregnant cows to search for possible markers which are [...] Read more.
Pregnancy is a physiological state that can be described, from a biochemical point of view, using protein patterns. The present study focused on the comparison of protein patterns between the saliva and plasma of pregnant cows to search for possible markers which are present both in plasma and saliva. Saliva and plasma were collected from healthy, pregnant (3–4 months) and non-pregnant (C; n = 4) cows aged between 4 and 8 years (P; n = 8) from the same farm. Biological material was analyzed using 2D electrophoresis and MS identification. Among identified spots, there were those which could be related to pregnancy (e.g., apolipoproteins I and II in all examined matrices or transforming growth factor-beta-induced protein ig-h3 in albumin-free plasma) as well as those which are responsible for regulating of cellular processes (e.g., pyruvate kinase and aspartate aminotransferase in all examined matrices, or lactate dehydrogenase, phosphoglycerate kinase, and NADH dehydrogenase in plasma). Further identification of common spots and those only specific to saliva as well as the comparison between other periods of pregnancy are necessary; it is already clear that saliva can be considered a valuable diagnostic matrix containing potential markers of physiological and pathological status. Full article
(This article belongs to the Special Issue Saliva and Serum Markers in Animals Health Monitoring)
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