Special Issue "Refinements to Animal Models for Biomedical Research"
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 48942
A printed edition of this Special Issue is available here.
Interests: analgesia; pain; production animals; cattle; sheep; pigs; poultry
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The value of publications focused specifically on refinement of animal models in biomedical research is immense. Relying on authors to report their science and include adequate details on methodology, adverse events and outcomes for animals used in biomedical research is unlikely to uphold the 3Rs (refine, reduce, replace) of animal research. Despite the aims of the ARRIVE (Animals in Research: Reporting in vivo Experiments) guidelines published in 2010 and revised in 2019, there is still room for improvement in the level of detail included in publications 1, 2. As examples, details on husbandry, anaesthesia, analgesia, post-procedural monitoring, morbidity and mortality are often scant and therefore make efforts at refinement of models more challenging.
Refinement refers to optimizing the welfare of research animals by avoiding or minimising pain, fear and distress and by maintaining animals in conditions that promote their health and well-being 3. Key contributors to efforts at refinement include anaesthesia, analgesia and post-operative care of animals. Ultimately, refinements should achieve improvements in animal welfare and quality of science.
We invite submissions describing efforts at refinement to animal models to increase the evidence base and to identify and explore opportunities for improving animal welfare and the quality of science.
- Kilkenny C, Browne WJ, Cuthill IC, et al. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research. PLOS Biology 2010; 8: e1000412. DOI: 10.1371/journal.pbio.1000412.
- Percie du Sert N, Hurst V, Ahluwalia A, et al. The ARRIVE guidelines 2019: updated guidelines for reporting animal research. bioRxiv 2019: 703181. DOI: 10.1101/703181.
- Prescott MJ and Lidster K. Improving quality of science through better animal welfare: the NC3Rs strategy. Lab Anim (NY) 2017; 46: 152-156. 2017/03/23. DOI: 10.1038/laban.1217.
Dr. Gabrielle Musk
Manuscript Submission Information
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- animal model
- animal welfare