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Paratuberculosis in Livestock: Innovative Approaches for Early Diagnosis and Disease...
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Paratuberculosis in Livestock: Innovative Approaches for Early Diagnosis and Disease Control

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 5724

Special Issue Editor

Dr. Giulietta Minozzi

E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Sciences, University of Milan, Via Dell'Università 6, 26900 Lodi, LO, Italy
Interests: animal genetics; genomics; breeding; diversity; conservation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a significant problem in livestock and its control and prevention is a priority to reduce economic losses and health risks. Most of the research carried out on this disease has been on cattle. The control of disease is dependent on the accuracy and timeliness of diagnosis, and also on farm management practices, including nutrition, housing, and breeding. Sheep and goats are important livestock species, both in developed and developing countries. Therefore, new approaches for selective breeding of disease-resistant animals and improved diagnosis using biomarkers can improve the health and welfare of these species. This issue will be focused on paratuberculosis (PT) in sheep and goats, a disease caused by the Mycobacterium avium subspecies paratuberculosis, and new molecular approaches to its diagnosis and disease control.

Dr. Giulietta Minozzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • paratuberculosis
  • transcriptome
  • proteome
  • genomics
  • Mycobacterium
  • sheep
  • goats

Published Papers (2 papers)

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13 pages, 1284 KiB  
Article
Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression
by Cristina Blanco Vázquez, Ana Balseiro, Marta Alonso-Hearn, Ramón A. Juste, Natalia Iglesias, Maria Canive and Rosa Casais
Animals 2021, 11(5), 1370; https://doi.org/10.3390/ani11051370 - 12 May 2021
Cited by 8 | Viewed by 2600
Abstract
Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy industry. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) [...] Read more.
Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy industry. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10.6) and diffuse (log2 fold-change = 6.8) PTB-associated lesions compared to animals without lesions. This study analyzes the potential use of ITLN2, a protein that has been described as fundamental in the innate immune response to infections, as a biomarker of MAP infection. The presence of ITLN2 was investigated by quantitative immunohistochemical analysis of ICV samples of 20 Holstein Friesian cows showing focal (n = 5), multifocal (n = 5), diffuse (n = 5) and no histological lesions (n = 5). Significant differences were observed in the mean number of ITLN2 immunostained goblet and Paneth cells between the three histopathological types and the control. The number of immunolabelled cells was higher in the focal histopathological type (116.9 ± 113.9) followed by the multifocal (108.7 ± 140.5), diffuse (76.5 ± 97.8) and control types (41.0 ± 81.3). These results validate ITLN2 as a post-mortem biomarker of disease progression. Full article
(This article belongs to the Special Issue Paratuberculosis in Livestock: Innovative Approaches for Early Diagnosis and Disease Control)
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19 pages, 581 KiB  
Review
Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats
by Palazzo Fiorentina, Camillo Martino, Ylenia Mancini, Maria Grazia De Iorio, John L. Williams and Giulietta Minozzi
Animals 2021, 11(7), 1912; https://doi.org/10.3390/ani11071912 - 27 Jun 2021
Cited by 2 | Viewed by 2447
Abstract
Johne’s disease (JD) is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on [...] Read more.
Johne’s disease (JD) is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on cattle, but interest in the pathogenesis and diagnosis of this disease in sheep and goats is greatest in developing countries. Sheep and goats are also a relevant part of livestock production in Europe and Australia, and these species provide an excellent resource to study and better understand the mechanism of survival of MAP and gain insights into possible approaches to control this disease. This review gives an overview of the literature on paratuberculosis in sheep and goats, highlighting the immunological aspects and the potential for “omics” approaches to identify effective biomarkers for the early detection of infection. As JD has a long incubation period before the disease becomes evident, early diagnosis is important to control the spread of the disease. Full article
(This article belongs to the Special Issue Paratuberculosis in Livestock: Innovative Approaches for Early Diagnosis and Disease Control)
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