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Functional Feeds to Enhance Health and Disease Resistance in Aquaculture...
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Functional Feeds to Enhance Health and Disease Resistance in Aquaculture Species

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 15 March 2027 | Viewed by 630

Editor

Dr. Jian'an Xian

E-Mail Website
Guest Editor
Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Interests: nutrition; immunity; disease resistance; aquatic animals; feed
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition is one of the most important factors affecting the immunity and disease resistance of aquatic animals. Nutritional balance is the basic element for aquatic animals to obtain superior immunity. On the other hand,  feed additives such as polysaccharides, antioxidants, probiotics, prebiotics and Chinese herbs, which were found to promote immune response and disease resistance, were used as immunostimulants for aquatic animals. These studies will promote the green and sustainable development of aquaculture. The aim of this Special Issue is to publish original research papers or reviews concerning nutrition of aquatic animals and the interrelations between nutrition, health and disease resistance.

Dr. Jian'an Xian
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • immunity
  • disease resistance
  • aquatic animals
  • feed
  • feed additives

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Published Papers (1 paper)

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Research

28 pages, 16095 KB  
Article
Chlorogenic Acid Improves Intestinal Health in Largemouth Bass (Micropterus salmoides) by Enhancing Antioxidant Defense, Reducing Inflammatory Responses, and Modulating the Gut Microbiota
by Qin Zhang, Lan Li, Dehong Lan, Miao Zhou, Ziyang Yuan, Tong Tong, Yongqiang Liu, Zhichang He, Zhongbao Guo and Weiguang Kong
Animals 2026, 16(11), 1668; https://doi.org/10.3390/ani16111668 - 29 May 2026
Viewed by 428
Abstract
Intestinal oxidative imbalance, inflammatory activation, and microbial dysbiosis are increasingly recognized as major factors affecting the health status of intensively cultured largemouth bass (Micropterus salmoides). Chlorogenic acid (CGA) is a plant-derived polyphenolic compound that is well known for its antioxidant and [...] Read more.
Intestinal oxidative imbalance, inflammatory activation, and microbial dysbiosis are increasingly recognized as major factors affecting the health status of intensively cultured largemouth bass (Micropterus salmoides). Chlorogenic acid (CGA) is a plant-derived polyphenolic compound that is well known for its antioxidant and anti-inflammatory properties. Although its inclusion as a dietary supplement in aquafeeds has garnered increasing interest, its effects on intestinal health in largemouth bass under normal rearing conditions remain largely unknown. Hence, the present investigation was designed to elucidate how incrementally elevated dietary CGA concentrations modulate oxidative capacity, inflammatory gene expression, mucosal histological features, and enteric microbiota structure in juvenile largemouth bass. In this study, largemouth bass were fed diets containing 0, 200, 400, or 600 mg/kg CGA for 70 days, and we evaluated intestinal antioxidant capacity, inflammation-related transcriptional responses, histomorphology, and gut microbiota were assessed. The results demonstrated that CGA supplementation significantly raised intestinal total antioxidant capacity as well as the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, while substantially decreasing malondialdehyde levels (p < 0.05). The transcription levels of cat, gsh-px, gst, sod, nrf2, and ucp2 were markedly upregulated, whereas keap1 expression was downregulated (p < 0.05). CGA supplementation also reduced the transcription levels of several proinflammatory genes, including il-1β, il-6, il-8, tnf-α, nf-κb, p50, map3k, jak2, as well as stat3, while significantly elevating il-10 expression, in the 200 and 400 mg/kg groups, tgf-β expression was also lowered (p < 0.05). Histological examination revealed that CGA supplementation influenced intestinal morphology in a dose-dependent manner; the most consistent improvements in villus length, villus width, and muscularis thickness occurred at the 400 mg/kg level, whereas the 600 mg/kg level showed weaker effects in several parameters compared with the control. Furthermore, 16S rRNA sequencing indicated that CGA altered microbial diversity, community structure, and predicted functional profiles in the intestine. In summary, dietary CGA supplementation was associated with enhanced intestinal antioxidant capacity, modified inflammation-related transcriptional responses, changes in intestinal morphology, and shifts in the gut microbial community of largemouth bass. Within the tested dose range, the 400 mg/kg group exhibited relatively favorable responses in several measured indicators under the present experimental conditions. Full article
(This article belongs to the Special Issue Functional Feeds to Enhance Health and Disease Resistance in Aquaculture Species)
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