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Gout, Urate, and Crystal Deposition Disease, Volume 3, Issue 1

March 2025 - 4 articles

Cover Story: China now has the highest number of gout cases globally; its prevalence is increasing with earlier onset and rising numbers of cases among adolescents. This Review summarizes a decade of epidemiology, clinical, and research advances in China, including hyperuricemia classification-based urate-lowering therapy, urine alkalization strategies, and genetic insights into drug response. We also explore the emerging roles of metabolomics and gut microbiota in non-invasive diagnosis and precision management. View this paper

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Review

1 Citations

2,511 Views

17 Pages

Convergence of Psoriatic Arthritis and Hyperuricemia: A Review of Emerging Data from This New Concept Called “Psout”

Renaud Felten,
Laura Widawski,
Pierre-Marie Duret,
Lionel Spielmann and
Laurrent Messer

Gout Urate Cryst. Depos. Dis.2025, 3(1), 4;https://doi.org/10.3390/gucdd3010004

17 March 2025

This review examines the concept of “psout”, an overlap syndrome of hyperuricemic psoriatic arthritis (HU-PsA) and co-existing gout and PsA. The manuscript explores its epidemiology, pathophysiology, clinical implications, and treatment s...

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Perspective

4,566 Views

7 Pages

Treat to Target in Gout Management: A Critical Reappraisal of Current Strategies

Anusha Moses,
Martijn Oude Voshaar,
Mart van de Laar and
Tim L. Th. Jansen

Gout Urate Cryst. Depos. Dis.2025, 3(1), 3;https://doi.org/10.3390/gucdd3010003

28 February 2025

Gout management strategies remain a topic of debate, particularly regarding the efficacy of treat-to-target (T2T) and treat-to-avoid-symptoms (T2S) approaches. T2T, endorsed by major rheumatology societies, involves systematic serum urate (sUA) monit...

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Perspective

1 Citations

4,475 Views

8 Pages

Can Urate Lowering Therapy Be Stopped in Gout? Rationale and Design of Two Large Randomised Trials

Pascal Richette,
Marcel Flendrie,
Leo A. B. Joosten and
Noortje van Herwaarden

Gout Urate Cryst. Depos. Dis.2025, 3(1), 2;https://doi.org/10.3390/gucdd3010002

22 January 2025

Lifelong urate-lowering therapy (ULT) is recommended for gout to prevent flares and urate deposition. However, concerns about its adherence, long-term side effects, and the necessity of continuous treatment after achieving remission raise critical qu...

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Review

5 Citations

7,192 Views

21 Pages

Gout in China

Aichang Ji,
Zibin Tian,
Yongyong Shi,
Riku Takei,
Shun-Jen Chang,
Ronald M. L. Yip,
Huiyong Yin and
Changgui Li

Gout Urate Cryst. Depos. Dis.2025, 3(1), 1;https://doi.org/10.3390/gucdd3010001

31 December 2024

Gout is a common inflammatory joint disease in China. In recent years, the prevalence of gout in China has been increasing and the onset age of gout has been trending younger. The common risk factors for gout in China include hyperuricemia, age, sex,...

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Gout Urate Cryst. Depos. Dis. - ISSN 2813-4583

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