1.4CiteScore
43 daysTime to First Decision

Gout, Urate, and Crystal Deposition Disease, Volume 2, Issue 4

December 2024 - 4 articles

Cover Story: Epigenetic reprogramming is increasingly recognized as a factor for understanding the variability of inflammatory response in gout. While monosodium urate (MSU) crystals drive the disease, not all hyperuricemic individuals develop gout, indicating other implications. Epigenetic mechanisms like DNA methylation, histone modifications, and non-coding RNAs influence immune activation, offering insights into potential therapies for dysregulated inflammation in gout. View this paper

Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
You may sign up for email alerts to receive table of contents of newly released issues.
PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (4)

Select all

Review

4 Citations

7,152 Views

16 Pages

Year in Review 2023: Gout Clinical Research

Greg Challener and
Chio Yokose

Gout Urate Cryst. Depos. Dis.2024, 2(4), 354-369;https://doi.org/10.3390/gucdd2040025

8 November 2024

Gout is the most common inflammatory arthritis, with a growing global disease burden. This conference report summarizes nine impactful publications dating from 11/2022 to 10/2023 to inform and improve clinical care in gout. The articles we present he...

Full Article

Article

1 Citations

2,893 Views

15 Pages

Assessing Changes in Vascular Inflammation and Urate Deposition in the Vasculature of Gout Patients After Administration of Pegloticase Using Positron Emission Tomography and Dual-Energy Computed Tomography—A Pilot Study

Ira Khanna,
Venkatesh Mani,
Renata Pyzik,
Audrey Kaufman,
Weiwei Chi,
Emilia Bagiella,
Philip Robson and
Yousaf Ali

Gout Urate Cryst. Depos. Dis.2024, 2(4), 339-353;https://doi.org/10.3390/gucdd2040024

6 November 2024

We assessed changes in vascular inflammation and monosodium urate (MSU)-coded deposits after administration of Pegloticase in the vasculature of tophaceous gout patients using 18F-fluorodeoxyglucose (18F-FDG) Positron emission tomography/computed tom...

Full Article

Review

5 Citations

2,980 Views

14 Pages

Epigenomic Reprogramming in Gout

Ancuta R. Straton,
Brenda Kischkel,
Tania O. Crișan and
Leo A. B. Joosten

Gout Urate Cryst. Depos. Dis.2024, 2(4), 325-338;https://doi.org/10.3390/gucdd2040023

1 November 2024

Gout is a crystal-induced arthropathy in which monosodium urate (MSU) crystals precipitate within joints as a result of persistent hyperuricemia and elicit an inflammatory response. An intriguing aspect is the occurrence of gout in only 10–15%...

Full Article

Article

2 Citations

5,120 Views

10 Pages

A Novel Polarized Light Microscope for the Examination of Birefringent Crystals in Synovial Fluid

John D. FitzGerald,
Chesca Barrios,
Tairan Liu,
Ann Rosenthal,
Geraldine M. McCarthy,
Lillian Chen,
Bijie Bai,
Guangdong Ma and
Aydogan Ozcan

Gout Urate Cryst. Depos. Dis.2024, 2(4), 315-324;https://doi.org/10.3390/gucdd2040022

22 October 2024

Background: The gold standard for crystal arthritis diagnosis relies on the identification of either monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals in synovial fluid. With the goal of enhanced crystal detection, we adapted a standard...

Full Article

Get Alerted

Add your email address to receive forthcoming issues of this journal.

Gout Urate Cryst. Depos. Dis. - ISSN 2813-4583|Creative Common CC BY license

Imprint

Download Flyer