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90 pages, 658 KiB

Open AccessConference Report

Abstracts of the 4th International Electronic Conference on Antibiotics

by Manuel Simões and Marc Maresca

Med. Sci. Forum 2025, 35(1), 1; https://doi.org/10.3390/msf2025035001 - 2 Jul 2025

Viewed by 569

Abstract

The 4th International Electronic Conference on Antibiotics (ECA2025) was an online conference held on 21–23 May 2025, organized by the MDPI journal Antibiotics. This event aims to bring together researchers and scholars to discuss a wide range of topics covering the aim and scope of Antibiotics. We envision this conference as a highly interactive forum open to diverse interaction between its participants. It serves as a platform covering a broad range of topics, publishing papers on all aspects of antibiotics and encompassing the general fields of biochemistry, chemistry, genetics, microbiology, and pharmacology. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Antibiotics)

8 pages, 224 KiB

Open AccessProceeding Paper

Antimicrobial Resistance and Virulence in Escherichia coli from Broiler Production Unit: Genetic Insights for One Health

by Jessica Ribeiro, Vanessa Silva, Gilberto Igrejas, Sandrina A. Heleno, Filipa S. Reis and Patrícia Poeta

Med. Sci. Forum 2025, 35(1), 2; https://doi.org/10.3390/msf2025035002 - 7 Jul 2025

Viewed by 201

Abstract

The overuse of antibiotics in livestock contributes to antimicrobial resistance and zoonotic risk. This study investigated 19 Escherichia coli isolates from broiler feces (Savinor, Portugal), characterizing resistance genes, virulence factors, integrases, and phylogenetic groups by PCR. Most isolates carried ampC, tetA, blaCTX-M, and qnrS; all harbored fimA, and six had int1. Phylogroup A predominated. Resistance was mainly found in commensal groups, highlighting adaptation to poultry environments. The findings underscore the need for regional antimicrobial resistance monitoring and One Health strategies. Stewardship, biosecurity, and alternative measures are vital to mitigate antimicrobial resistance spread and zoonotic potential. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Antibiotics)

11 pages, 5546 KiB

Open AccessProceeding Paper

RhsP2 Protein as a New Antibacterial Toxin Targeting RNA

by Tamara Nami Haj Marza

Med. Sci. Forum 2025, 35(1), 3; https://doi.org/10.3390/msf2025035003 - 24 Jul 2025

Viewed by 185

Abstract

Many bacteria, such as Pseudomonas aeruginosa, have encoded many toxins like RhsP2 that target non-coding RNAs (ncRNAs) in a similar mechanism to ART components; bacterial RNA loses its function of amino acid translation. A virtual screening approach was used to investigate RhsP2, which targets 16s rRNAs and then disrupts the translation of bacterial amino acids to proteins. Rifamycin is the bioreference as it forms a stable complex with the bacterial RNA in its active sites. Using different docking software can determine the best predicted conformations between RhsP2/16S and rRNA, and analyzing the docking score for both Affinity Binding and the root mean square deviation (RMSD) of particle coordinates helps choose the most appropriate drugs by using tools such as bioinformatics platforms and databases. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Antibiotics)

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