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Nanomanufacturing, Volume 2, Issue 1
March 2022 - 4 articles
Cover Story: Nanoparticles (NPs) are diverse nanostructures engineered into a variety of shapes, sizes, and surface chemistries with intended use for a broad range of therapeutic and non-therapeutic applications. Where NPs are used as therapeutic agents (e.g., nanomedicine), they must cross several physical barriers and mechanisms to overcome the cell membrane. Exploitable natural uptake mechanisms, namely, passive and endocytic are used to facilitate efficient cellular uptake. This review explores the exploitation of endocytic pathways for mainly inorganic non-spherical cellular uptake. Experimental determination of cellular uptake of different NPs in different environments can be laborious and expensive; therefore, we also review the role of mathematical modeling as a predictive tool for non-spherical NP cellular uptake. View this paper
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Nanomanufacturing - ISSN 2673-687X