Forensic Sciences, Volume 5, Issue 3
2025 September - 19 articles
Cover Story: Anabolic–androgenic steroids (AASs) used for performance enhancement may cause neurotoxicity. This narrative review summarizes evidence on neurochemical changes, brain structure/function, cognition and psychiatric outcomes. Chronic AASs exposure disrupts serotonin and dopamine, promoting mood symptoms, aggression and cognitive deficits. Alterations in prefrontal and limbic regions suggest possible long-term damage. AASs are associated with higher risks of depression, anxiety and psychosis, potentially via hormonal dysregulation and neuroinflammation; polysubstance use worsens effects. Evidence supports a link, but mechanisms and long-term consequences remain unclear, underscoring the need for biomarkers, targeted interventions, and prevention/education. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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