Next Article in Journal
Formulation and Evaluation of Verdant Tablets Containing Saponin-Coalesced Silver Nanoparticles Got from Fenugreek Seed Extract
Previous Article in Journal
An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Chemistry Proceedings
Volume 7
Issue 1
10.3390/chemproc2022007077
chemproc-logo
Submit to this Journal
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Porous Materials as Platforms for the Delivery of Polyphenols †

by
Denisa Ficai
1,2,3,*,
Ludmila Motelica
1,3,
Gabriela Petrisor
3,4,
Irina Fierascu
5,
Radu Claudiu Fierascu
5,
Anton Ficai
2,3,4 and
Coralia Bleotu
6
1
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh Polizu 1-7, 060042 Bucharest, Romania
2
National Research Center for Food Safety, University POLITEHNICA of Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania
3
National Centre of Micro and Nanomaterials, University POLITEHNICA of Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania
4
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh Polizu 1-7, 060042 Bucharest, Romania
5
National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, Spl. Independentei 202, 060021 Bucharest, Romania
6
Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Avenue, 030304 Bucharest, Romania
*
Author to whom correspondence should be addressed.
†
Presented at the 17th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 27–29 October 2021.
Chem. Proc. 2022, 7(1), 77; https://doi.org/10.3390/chemproc2022007077
Published: 12 May 2022
(This article belongs to the Proceedings of The 17th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM)
Browse Figure
Versions Notes

Drug delivery systems are intensively studied for a wide range of biomedical applications [1,2,3]. A special class of materials is related to porous materials, which have the ability to host and release biological active agents (BAAs). The release of biological active agents can be tuned according to needs. Mesoporous silica has a history of about 30 years and can be used for the release of a wide range of BAAs. The release is dependent on the size of the pores and can be further tuned based on the surface functionalization [4].
Starting from the advantages of the mesoporous silica supports, innovative drug delivery systems can be developed in order to obtain controlled, targeted drug delivery systems that are able to maintain the therapeutic needs of the BAAs (Figure 1). In this work, several examples of drug delivery systems based on mesoporous silica and different polyphenols will be discussed, highlighting the potential of their use in the treatment of different diseases, and especially, in the treatment of dysbiosis.

Author Contributions

Conceptualization, D.F., I.F., and A.F.; Methodology, D.F., L.M. and G.P.; Writing—Original Draft Preparation, L.M. and G.P.; Writing—Review & Editing, R.C.F., A.F. and C.B.; Supervision, R.C.F., A.F. and C.B.; Project Administration, D.F., I.F. and C.B. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by a grant from the Romanian National Authority for Scientific Research and Innovation, CNCS/CCCDI—UEFISCDI, project No. PN-III-P2-2.1-PED-2019-4018, contract 524PED/2020, within PNCDI III. Additionally, UPB is part of the COST action CA_20126: Network for research, innovation and product development on porous semiconductors and oxides 220/2020, and project number PN-III-P2-2.1-PED-2019-3166, contract 299PED/2020, within PNCDI III.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Sonmez, M.; Ficai, D.; Ficai, A.; Alexandrescu, L.; Georgescu, M.; Trusca, R.; Gurau, G.; Titu, M.A.; Andronescu, E. Applications of mesoporous silica in biosensing and controlled release of insulin. Int. J. Pharmaceut. 2018, 549, 179–200. [Google Scholar] [CrossRef] [PubMed]
  2. Popescu, S.; Ardelean, I.L.; Gudovan, D.; Radulescu, M.; Ficai, D.; Ficai, A.; Vasile, B.S.; Andronescu, E. Multifunctional materials such as MCM-41/Fe3O4/folic acid as drug delivery system. Rom. J. Morphol. Embryol. 2016, 57, 483–489. [Google Scholar] [PubMed]
  3. Gunduz, O.; Yetmez, M.; Sonmez, M.; Georgescu, M.; Alexandrescu, L.; Ficai, A.; Ficai, D.; Andronescu, E. Mesoporous Materials Used in Medicine and Environmental Applications. Curr. Top. Med. Chem. 2015, 15, 1501–1515. [Google Scholar] [CrossRef] [PubMed]
  4. Kresge, C.T.; Leonowicz, M.E.; Roth, W.J.; Vartuli, J.C.; Beck, J.S. Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature 1992, 359, 710–712. [Google Scholar] [CrossRef]
Chemproc 07 00077 g001 550
Figure 1. Mesoporous silica-based drug delivery system for the treatment of dysbiosis.
Figure 1. Mesoporous silica-based drug delivery system for the treatment of dysbiosis.
Chemproc 07 00077 g001
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Ficai, D.; Motelica, L.; Petrisor, G.; Fierascu, I.; Fierascu, R.C.; Ficai, A.; Bleotu, C. Porous Materials as Platforms for the Delivery of Polyphenols. Chem. Proc. 2022, 7, 77. https://doi.org/10.3390/chemproc2022007077

AMA Style

Ficai D, Motelica L, Petrisor G, Fierascu I, Fierascu RC, Ficai A, Bleotu C. Porous Materials as Platforms for the Delivery of Polyphenols. Chemistry Proceedings. 2022; 7(1):77. https://doi.org/10.3390/chemproc2022007077

Chicago/Turabian Style

Ficai, Denisa, Ludmila Motelica, Gabriela Petrisor, Irina Fierascu, Radu Claudiu Fierascu, Anton Ficai, and Coralia Bleotu. 2022. "Porous Materials as Platforms for the Delivery of Polyphenols" Chemistry Proceedings 7, no. 1: 77. https://doi.org/10.3390/chemproc2022007077

APA Style

Ficai, D., Motelica, L., Petrisor, G., Fierascu, I., Fierascu, R. C., Ficai, A., & Bleotu, C. (2022). Porous Materials as Platforms for the Delivery of Polyphenols. Chemistry Proceedings, 7(1), 77. https://doi.org/10.3390/chemproc2022007077

Article Metrics

Back to TopTop