The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review
Abstract
:1. Introduction
Research Question
2. Materials and Methods
Research Strategy and Literature Search
3. Research Evidence
3.1. Pre-Clinical Data
3.2. Clinical Data
3.2.1. Effects in Men with HPV Infections
3.2.2. Effects in Pre-Neoplastic and Neoplastic Cervical Lesions
4. Conclusions, Limitations and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Year | Type of Study | Aim | Findings Description |
---|---|---|---|---|
Moktar A. [32] | 2009 | In vitro study | Evaluate the Ellagic acid effect as DNA breaks protector. | Ellagic acid is able to inhibit the DNA breaks in cells infected by HPV infection and treated with cigarette smoke condensate. |
Park SW. [33] | 2014 | In vitro study | Evaluate the Ellagic acid effect in protecting the cells from virus infection. | Ellagic acid interacts with the human cells in the early stage of human rhinoviruses infections to protect the cells from the virus destruction. |
Balderrama-Carmona AP. [34] | 2021 | In vitro study | To study the antiviral and antioxidant properties of Annona muricata. | Annona muricata seems to have a positive effect on reducing oxidative stress in human erythrocytes and viral infections. |
Author | Year | Type of Study | Aim | Findings Description |
---|---|---|---|---|
Cai T. [35] | 2022 | Phase I-II study | To evaluate the effects of a 3-month treatment with ellagic acid and Annona muricata in men with oligospermia and HPV-related infections. | Ellagic acid and Annona muricata complex improved HPV-DNA clearance and seminal parameters. |
La Vignera S. [36] | 2022 | Retrospective case–control study | To evaluate the effects of ellagic acid and Annona muricata in men with inefrtility and HPV infections. | Ellagic acid and Annona muricata complex improve semen quality and HPV-DNA clearance rate in patients with high-risk HPV infection |
Morosetti G. [37] | 2017 | Phase III study | To evaluate the effect of ellagic acid and Annona Muricata on viral clearance and/or cytological lesions in a group of women with HPV cervical infection. | Women treated with ellagic acid and Annona muricata complex were less likely to be diagnosed with an abnormal Pap smear at 6 and 12 months when compared with the control group. |
Moscato GMF. [38] | 2022 | Retrospective study | To compares the evolution of persistent cervical HPV infection in women treated with nonavalent vaccine or ellagic acid and Annona muricata. | The use of ellagic acid and Annona muricata seems an interesting clinical strategy in terms of increasing chance of HPV viral clearance. |
Le Donne M. [39] | 2017 | Pilot study | To investigate the anti-viral activity of ellagic acid and Annona muricata complex in women affected by low squamous intraepithelial lesion (L-SIL) related to HPV infections. | Ellagic acid and Annona muricata complex is able to improve the HPV viral clearance. |
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Cai, T.; Rizzo, M.; Liguori, G.; Palumbo, M.; Palmieri, A.; Gallelli, L. The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review. Uro 2023, 3, 54-60. https://doi.org/10.3390/uro3010008
Cai T, Rizzo M, Liguori G, Palumbo M, Palmieri A, Gallelli L. The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review. Uro. 2023; 3(1):54-60. https://doi.org/10.3390/uro3010008
Chicago/Turabian StyleCai, Tommaso, Michele Rizzo, Giovanni Liguori, Michele Palumbo, Alessandro Palmieri, and Luca Gallelli. 2023. "The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review" Uro 3, no. 1: 54-60. https://doi.org/10.3390/uro3010008