Intervenable Findings Are Common When ERCP Is Performed for Pediatric Patients When Large Duct Obstruction Is Found on Liver Biopsy: Initial Characterization
Abstract
Highlights
- Liver biopsy performed for the evaluation of abnormal liver function studies occasionally reveals large bile duct obstruction on histology.
- A minority of pediatric patients with large duct obstruction on liver biopsy undergo ERCP.
- Of those who undergo ERCP, 80% have a therapeutic endoscopic intervention with a favorable impact on clinical laboratory study trajectory.
Abstract
1. Introduction
2. Methods
2.1. Study Design and Data Source
2.2. Study Outcomes
2.3. Statistical Analysis
3. Results
3.1. Demographic and Clinical Characteristics of All Patients
3.2. Demographic and Clinical Characteristics of Patients Who Underwent ERCP
3.2.1. Demographics
3.2.2. Clinical Characteristics
3.3. ERCP Findings
3.4. Clinical Trajectory
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Overall | ERCP | |||
---|---|---|---|---|
No | Yes | ASD | ||
n | 85 | 70 | 15 | |
Age (mean (sd)) | 7.69 (6.66) | 7.51 (6.72) | 8.52 (6.49) | 0.153 |
Gender (%) | 0.345 | |||
Female | 51 (60.0) | 40 (57.1) | 11 (73.3) | |
Male | 34 (40.0) | 30 (42.9) | 4 (26.7) | |
Race (%) | 1.177 | |||
White | 40 (47.1) | 32 (45.7) | 8 (53.3) | |
Asian | 17 (20.0) | 17 (24.3) | 0 (0.0) | |
Black | 7 (8.2) | 7 (10.0) | 0 (0.0) | |
American Indian or Alaska Native | 3 (3.5) | 2 (2.9) | 1 (6.7) | |
Native Hawaiian or other Pacific Islander | 2 (2.4) | 2 (2.9) | 0 (0.0) | |
Other | 16 (18.8) | 10 (14.3) | 6 (40.0) | |
Ethnicity (%) | 0.553 | |||
Hispanic | 22 (25.9) | 15 (21.4) | 7 (46.7) | |
Non-Hispanic | 63 (74.1) | 55 (78.6) | 8 (53.3) | |
BMI (mean (sd)) | 19.03 (5.60) | 18.56 (5.12) | 21.00 (7.22) | 0.39 |
Total bilirubin (mean (sd)) | 4.61 (6.89) | 4.72 (7.42) | 4.16 (3.99) | 0.094 |
GGT (mean (sd)) | 353.30 (405.89) | 320.11 (413.45) | 497.13 (347.70) | 0.463 |
Alkaline phosphatase (mean (sd)) | 403.44 (251.38) | 395.79 (258.79) | 437.60 (219.90) | 0.174 |
AST (mean (sd)) | 343.80 (1194.58) | 387.72 (1315.75) | 144.67 (146.25) | 0.26 |
ALT (mean (sd)) | 251.99 (390.42) | 275.36 (425.59) | 147.60 (117.13) | 0.409 |
Platelet (mean (sd)) | 289.68 (183.68) | 279.24 (184.54) | 336.33 (178.34) | 0.315 |
INR (mean (sd)) | 1.19 (0.22) | 1.19 (0.22) | 1.17 (0.21) | 0.106 |
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Martin, M.; Lee, J.; Gugig, R.; Charville, G.; Barakat, M.T. Intervenable Findings Are Common When ERCP Is Performed for Pediatric Patients When Large Duct Obstruction Is Found on Liver Biopsy: Initial Characterization. Surgeries 2025, 6, 82. https://doi.org/10.3390/surgeries6040082
Martin M, Lee J, Gugig R, Charville G, Barakat MT. Intervenable Findings Are Common When ERCP Is Performed for Pediatric Patients When Large Duct Obstruction Is Found on Liver Biopsy: Initial Characterization. Surgeries. 2025; 6(4):82. https://doi.org/10.3390/surgeries6040082
Chicago/Turabian StyleMartin, Melissa, Justin Lee, Roberto Gugig, Greg Charville, and Monique T. Barakat. 2025. "Intervenable Findings Are Common When ERCP Is Performed for Pediatric Patients When Large Duct Obstruction Is Found on Liver Biopsy: Initial Characterization" Surgeries 6, no. 4: 82. https://doi.org/10.3390/surgeries6040082
APA StyleMartin, M., Lee, J., Gugig, R., Charville, G., & Barakat, M. T. (2025). Intervenable Findings Are Common When ERCP Is Performed for Pediatric Patients When Large Duct Obstruction Is Found on Liver Biopsy: Initial Characterization. Surgeries, 6(4), 82. https://doi.org/10.3390/surgeries6040082